Academic Journal
Cannabis in Adolescence: Lasting Cognitive Alterations and Underlying Mechanisms
| العنوان: | Cannabis in Adolescence: Lasting Cognitive Alterations and Underlying Mechanisms |
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| المؤلفون: | Scheyer, Andrew, Laviolette, Steven, Pelissier, Anne-Laure, Manzoni, Olivier |
| المساهمون: | Institut de Neurobiologie de la Méditerranée Aix-Marseille Université (INMED - INSERM U1249), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Western Ontario (UWO), Schulich School of Medicine and Dentistry, Médecine légale Hôpital de la Timone - APHM, Hôpital de la Timone CHU - APHM (TIMONE) |
| المصدر: | ISSN: 2578-5125 ; Cannabis and Cannabinoid Research ; https://amu.hal.science/hal-04133502 ; Cannabis and Cannabinoid Research, 2023, 8, pp.12 - 23. ⟨10.1089/can.2022.0183⟩. |
| بيانات النشر: | HAL CCSD Mary Ann Liebert Inc |
| سنة النشر: | 2023 |
| المجموعة: | Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
| مصطلحات موضوعية: | cannabis adolescence cognition, cannabis, adolescence, cognition, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] |
| الوصف: | International audience ; Cannabis consumption during adolescence is an area of particular concern, owing to changes in the social and political perception of the drug, and presents a scientific, medical, and economic challenge. Major social and economic interests continue to push toward cannabis legalization as well as pharmaceutical development. As a result, shifting perceptions of both legal and illicit cannabis use across the population have changed the collective evaluation of the potential dangers of the product. The wave of cannabis legalization therefore comes with new responsibility to educate the public on potential risks and known dangers associated with both recreational and medical cannabis. Among these is the risk of long-term cognitive and psychological consequences, particularly following early-life initiation of use, compounded by high-potency and/or synthetic cannabis, and heavy/frequent use of the drug. Underlying these cognitive and psychiatric consequences are lasting aberrations in the development of synaptic function, often secondary to epigenetic changes. Additional factors such as genetic risk and environmental influences or nondrug toxic insults during development are also profound contributors to these long-term functional alterations following adolescent cannabis use. Preclinical studies indicate that exposure to cannabinoids during specific windows of vulnerability (e.g., adolescence) impacts neurodevelopmental processes and behavior by durably changing dendritic structure and synaptic functions, including those normally mediated by endogenous cannabinoids and neuronal circuits. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | hal-04133502; https://amu.hal.science/hal-04133502; https://amu.hal.science/hal-04133502/document; https://amu.hal.science/hal-04133502/file/can.2022.0183.pdf |
| DOI: | 10.1089/can.2022.0183 |
| الاتاحة: | https://amu.hal.science/hal-04133502 https://amu.hal.science/hal-04133502/document https://amu.hal.science/hal-04133502/file/can.2022.0183.pdf https://doi.org/10.1089/can.2022.0183 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.C072616E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1089/can.2022.0183 |
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