Academic Journal
Dynamic Characteristic Analysis of Antibodies in Patients With COVID-19: A 13-Month Study
| العنوان: | Dynamic Characteristic Analysis of Antibodies in Patients With COVID-19: A 13-Month Study |
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| المؤلفون: | Shi, Danrong, Weng, Tianhao, Wu, Jie, Dai, Chunyan, Luo, Rui, Chen, Keda, Zhu, Miaojin, Lu, Xiangyun, Cheng, Linfang, Chen, Qiuqiang, Liu, Fumin, Wu, Zhigang, Wu, Haibo, Jin, Changzhong, Guo, Miao, Chen, Zhe, Wu, Nanping, Yao, Hangping, Zheng, Min |
| المصدر: | Frontiers in Immunology ; volume 12 ; ISSN 1664-3224 |
| بيانات النشر: | Frontiers Media SA |
| سنة النشر: | 2021 |
| المجموعة: | Frontiers (Publisher - via CrossRef) |
| الوصف: | There is a worldwide pandemic of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection; yet our understanding remains limited on the characteristic of antibodies, especially for dynamic long-term tracking. Sequential serum samples were collected up to 416 days post onset of symptoms (POS) from 102 patients who were hospitalized with coronavirus disease 2019 (COVID-19). Immunoglobulin (Ig)G, IgM, and IgA levels targeting SARS-CoV-2 spike 1 receptor-binding domain (S1-RBD), spike 2 extracellular domain (S2-ECD), and nucleocapsid protein (N) were quantified as well as neutralizing activity. We were pleasantly surprised to find that the antibody remained detective and effective for more than a year POS. We also found the varied reactions of different antibodies as time passed: N-IgA rose most rapidly in the early stage of infection, while S2-IgG was present at a high level in the long time of observation. This study described the long traceable antibody response of the COVID-19 and offered hints about targets to screen for postinfectious immunity and for vaccination development of SARS-CoV-2. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.3389/fimmu.2021.708184 |
| DOI: | 10.3389/fimmu.2021.708184/full |
| الاتاحة: | http://dx.doi.org/10.3389/fimmu.2021.708184 https://www.frontiersin.org/articles/10.3389/fimmu.2021.708184/full |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.C00F9D2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fimmu.2021.708184 |
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