Academic Journal
Synthesis and Antitumor Evaluation of Thiophene Analogs of Kigelinone
| العنوان: | Synthesis and Antitumor Evaluation of Thiophene Analogs of Kigelinone |
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| المؤلفون: | Valderrama, Jaime A., Espinoza, Omar, Rodriguez, Jaime, Theoduloz, Cristina |
| بيانات النشر: | BENTHAM SCIENCE PUBL LTD |
| سنة النشر: | 2024 |
| المجموعة: | Pontificia Universidad Católica de Chile: Repositorio UC |
| مصطلحات موضوعية: | Quinones, Benzo[b]thiophenes, Oxidative deprotection, Diels-Alder reaction, Regioisomers, Citotoxicity, LEISHMANICIDAL ACTIVITY, ANTIPROTOZOAL ACTIVITY, TABEBUIA-AVELLANEDAE, CYTOTOXICITY, FURANONAPHTHOQUINONES, HYDROQUINONES, RING, 03 Good Health and Well-being, 03 Salud y bienestar |
| الوصف: | The synthesis of kigelinone thiophene analogs and related naphtho[2,3-b] thiophene-4,9-quinones from 2-substituted 4,7-dimethoxybenzo[b]thiophenes via an oxidative deprotection, Diels-Alder, and oxidative aromatization reaction sequence is reported. The 2-substituted naphtho[2,3-b] thiophene-4,9-quinones display significant antitumor activity in the range IC50 1.1-47 mu M on a panel of four distinct human cancer cell lines. ; Fondo Nacional de Ciencia y Tecnologia |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 4 páginas; application/pdf |
| اللغة: | English |
| تدمد: | 1875-6255 1570-1786 |
| Relation: | https://doi.org/10.2174/157017809788490006; https://repositorio.uc.cl/handle/11534/77582; WOS:000267046600003 |
| DOI: | 10.2174/157017809788490006 |
| الاتاحة: | https://repositorio.uc.cl/handle/11534/77582 https://doi.org/10.2174/157017809788490006 |
| Rights: | acceso restringido |
| رقم الانضمام: | edsbas.C001CE50 |
| قاعدة البيانات: | BASE |
| تدمد: | 18756255 15701786 |
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| DOI: | 10.2174/157017809788490006 |