Academic Journal
The prognostic value of haematologic parameter changes during treatment in cervical cancer patients treated with definitive chemoradiotherapy
| العنوان: | The prognostic value of haematologic parameter changes during treatment in cervical cancer patients treated with definitive chemoradiotherapy |
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| المؤلفون: | Berna A. Yildirim, Ozan Cem Guler, Fatih Kose, Cem Onal |
| المصدر: | Journal of Obstetrics and Gynaecology, Vol 39, Iss 5, Pp 695-701 (2019) |
| بيانات النشر: | Taylor & Francis Group |
| سنة النشر: | 2019 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | cervical cancer, neutrophil, leucocyte, haemoglobin, chemoradiotherapy, Gynecology and obstetrics, RG1-991 |
| الوصف: | We retrospectively analysed the prognostic significance of changes in absolute neutrophil count (ANC), absolute lymphocyte count (ALC) and neutrophil/lymphocyte ratio (NLR) during treatment with definitive chemoradiotherapy (CRT) in 104 cervical cancer patients. The absolute white blood cell, ANC and ALC decrease during treatment, NLR increased throughout treatment and reached to a plateau at fifth week. The ANC and NLR after 3rd week of definitive CRT were significantly higher and ALC after 3rd week of treatment was significantly lower in patients with progressive disease compared patients with no evidence of disease. Patients in low-haematological risk (LHR) group had significantly higher number of patients with smaller tumour size, early stage disease and without lymph node metastasis. In multivariate analysis, high-haematological risk (HHR) group and lymph node metastasis were negative prognosticators of overall and disease-free survival (DFS). The presence of lymph node metastasis and HHR could serve as a predicative factor of poor prognosis for cervical cancer patients.IMPACT STATEMENT What is already known on this subject? The ANC and NLR after 3rd week of definitive CRT were significantly higher and ALC after 3rd week of treatment was significantly lower in patients with progressive disease compared patients with no evidence of disease. Patients in LHR group had significantly higher number of patients with smaller tumour size, early stage disease and without lymph node metastasis. Lymph node metastasis and HHR and were negative prognosticators of overall and disease-free survival (DFS). The presence of lymph node metastasis and HHR could serve as a predicative factor of poor prognosis for cervical cancer patients. What the results of this study add? Weekly changes in ANC, ALC, and NLR, especially after 3rd week of treatment are predictive factors of disease progression, not the high-risk features of disease. Furthermore, in HHR group more patients with extensive stage disease, larger tumour and lymph ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0144-3615 1364-6893 |
| Relation: | http://dx.doi.org/10.1080/01443615.2019.1586852; https://doaj.org/toc/0144-3615; https://doaj.org/toc/1364-6893; https://doaj.org/article/02b2db3c256345a8a26e5cf1502f6c13 |
| DOI: | 10.1080/01443615.2019.1586852 |
| الاتاحة: | https://doi.org/10.1080/01443615.2019.1586852 https://doaj.org/article/02b2db3c256345a8a26e5cf1502f6c13 |
| رقم الانضمام: | edsbas.BFF3B119 |
| قاعدة البيانات: | BASE |
| تدمد: | 01443615 13646893 |
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| DOI: | 10.1080/01443615.2019.1586852 |