Academic Journal
Urine selenium concentration is a useful biomarker for assessing population level selenium status.
| العنوان: | Urine selenium concentration is a useful biomarker for assessing population level selenium status. |
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| المؤلفون: | Phiri, Felix P, Ander, E Louise, Lark, R Murray, Bailey, Elizabeth H, Chilima, Benson, Gondwe, Jellita, Joy, Edward JM, Kalimbira, Alexander A, Phuka, John C, Suchdev, Parminder S, Middleton, Daniel RS, Hamilton, Elliott M, Watts, Michael J, Young, Scott D, Broadley, Martin R |
| بيانات النشر: | Elsevier BV |
| سنة النشر: | 2020 |
| المجموعة: | London School of Hygiene & Tropical Medicine: LSHTM Research Online |
| الوصف: | Plasma selenium (Se) concentration is an established population level biomarker of Se status, especially in Se-deficient populations. Previously observed correlations between dietary Se intake and urinary Se excretion suggest that urine Se concentration is also a potentially viable biomarker of Se status. However, there are only limited data on urine Se concentration among Se-deficient populations. Here, we test if urine is a viable biomarker for assessing Se status among a large sample of women and children in Malawi, most of whom are likely to be Se-deficient based on plasma Se status. Casual (spot) urine samples (n = 1406) were collected from a nationally representative sample of women of reproductive age (WRA, n =741) and school aged children (SAC, n=665) across Malawi as part of the 2015/16 Demographic and Health Survey. Selenium concentration in urine was determined using inductively coupled plasma mass spectrometry (ICP-MS). Urinary dilution corrections for specific gravity, osmolality, and creatinine were applied to adjust for hydration status. Plasma Se status had been measured for the same survey participants. There was between-cluster variation in urine Se concentration that corresponded with variation in plasma Se concentration, but not between households within a cluster, or between individuals within a household. Corrected urine Se concentrations explained more of the between-cluster variation in plasma Se concentration than uncorrected data. These results provide new evidence that urine may be used in the surveillance of Se status at the population level in some groups. This could be a cost-effective option if urine samples are already being collected for other assessments, such as for iodine status analysis as in the Malawi and other national Demographic and Health Surveys. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| Relation: | https://researchonline.lshtm.ac.uk/id/eprint/4655285/1/Urine%20selenium%20concentration%20is%20a%20useful%20biomarker%20for%20assessing%20population%20level%20selenium%20status.pdf; Phiri, Felix P; Ander, E Louise; Lark, R Murray; Bailey, Elizabeth H; Chilima, Benson; Gondwe, Jellita; Joy, Edward JM ; Kalimbira, Alexander A; Phuka, John C; Suchdev, Parminder S; +5 more. Middleton, Daniel RS; Hamilton, Elliott M; Watts, Michael J; Young, Scott D; Broadley, Martin R; (2020) Urine selenium concentration is a useful biomarker for assessing population level selenium status. Environment international, 134. 105218-. ISSN 0160-4120 DOI: https://doi.org/10.1016/j.envint.2019.105218 |
| الاتاحة: | https://researchonline.lshtm.ac.uk/id/eprint/4655285/ https://researchonline.lshtm.ac.uk/id/eprint/4655285/1/Urine%20selenium%20concentration%20is%20a%20useful%20biomarker%20for%20assessing%20population%20level%20selenium%20status.pdf |
| Rights: | cc_by_nc_nd |
| رقم الانضمام: | edsbas.BFE4BA0F |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |