Academic Journal
Epigenetic regulatory differentiation of hematopoietic stem cells to the red lineage Running head: Epigenetics of erythropoiesis
| العنوان: | Epigenetic regulatory differentiation of hematopoietic stem cells to the red lineage Running head: Epigenetics of erythropoiesis |
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| المؤلفون: | Li, Hong-Xing, Chai, Yi-Hong, Sun, Xiao-Hong, He, Xiao-Xia, Xi, Ya-Ming |
| المساهمون: | Scientific Research Fund of the First Hospital of Lanzhou University |
| المصدر: | Reproductive and Developmental Medicine ; ISSN 2096-2924 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health) |
| سنة النشر: | 2024 |
| الوصف: | The differentiation process from hematopoietic (HSCs) to mature red blood cells (RBCs) is characterized by remarkable precision and is tightly controlled from the initial lineage commitment to eventual terminal differentiation. Erythropoiesis is the dynamic journey of HSCs through various functional and phenotypic stages. The physiological course of erythrogenesis is intricately linked to significant changes in chromatin accessibility, necessitating precise coordination of transcription factors and epigenetic elements. This review presents a comprehensive overview of recent investigations into the molecular-level epigenetic regulatory factors that influence differentiation of the erythroid lineage. This encompasses the exploration of transcriptional, post-transcriptional, and post-translational regulatory processes. The intricate interplay of epigenetic and transcriptional regulatory networks in erythroid differentiation not only enhances our understanding of this fundamental biological process, but also provides valuable insights into the underlying mechanisms contributing to the pathogenesis of disorders associated with abnormal erythroid development. These findings hold significant promise for the development of novel therapeutic strategies to address these diseases and improve patient outcomes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1097/rd9.0000000000000092 |
| DOI: | 10.1097/RD9.0000000000000092 |
| الاتاحة: | http://dx.doi.org/10.1097/rd9.0000000000000092 https://journals.lww.com/10.1097/RD9.0000000000000092 |
| Rights: | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| رقم الانضمام: | edsbas.BFD84C0D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1097/rd9.0000000000000092 |
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