Academic Journal
Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and beta-catenin
العنوان: | Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and beta-catenin |
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المؤلفون: | OTERO K, TURNBULL IR, POLIANI, Pietro Luigi, VERMI, William, CERUTTI E, AOSHI T, TASSI I, TAKAI T, STANLEY SL, MILLER M, SHAW AS, COLONNA M. |
المساهمون: | Otero, K, Turnbull, Ir, Poliani, Pietro Luigi, Vermi, William, Cerutti, E, Aoshi, T, Tassi, I, Takai, T, Stanley, Sl, Miller, M, Shaw, A, Colonna, M. |
سنة النشر: | 2009 |
مصطلحات موضوعية: | Macrophage survival, DAP12, beta-catenin |
الوصف: | Macrophage colony-stimulating factor (M-CSF) influences the proliferation and survival of mononuclear phagocytes through thereceptor CSF-1R. The adaptor protein DAP12 is critical for the unction of mononuclear phagocytes. DAP12-mutant mice and humans have defects in osteoclasts and microglia, as well as rain and bone abnormalities. Here we show DAP12 deficiency impaired the M-CSF-induced proliferation and survival of acrophages in vitro. DAP12-deficient mice had fewer microglia in defined central nervous system areas, and DAP12-deficient rogenitors regenerated myeloid cells inefficiently after bone arrow transplantation. Signaling by M-CSF through CSF-1R induced the stabilization and nuclear translocation of b-catenin, which activated genes involved in the cell cycle. DAP12 was essential for phosphorylation and nuclear accumulation of b-catenin. Our results provide a mechanistic explanation for the many defects of DAP12-deficient mononuclear phagocytes. |
نوع الوثيقة: | article in journal/newspaper |
اللغة: | English |
Relation: | info:eu-repo/semantics/altIdentifier/pmid/19503107; info:eu-repo/semantics/altIdentifier/wos/WOS:000267142600013; volume:10(7); firstpage:734; lastpage:743; numberofpages:10; journal:NATURE IMMUNOLOGY; https://hdl.handle.net/20.500.11768/162476 |
DOI: | 10.1038/ni.1744 |
الاتاحة: | https://hdl.handle.net/20.500.11768/162476 https://doi.org/10.1038/ni.1744 |
رقم الانضمام: | edsbas.BFC8BA34 |
قاعدة البيانات: | BASE |
DOI: | 10.1038/ni.1744 |
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