Academic Journal

Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and beta-catenin

التفاصيل البيبلوغرافية
العنوان: Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and beta-catenin
المؤلفون: OTERO K, TURNBULL IR, POLIANI, Pietro Luigi, VERMI, William, CERUTTI E, AOSHI T, TASSI I, TAKAI T, STANLEY SL, MILLER M, SHAW AS, COLONNA M.
المساهمون: Otero, K, Turnbull, Ir, Poliani, Pietro Luigi, Vermi, William, Cerutti, E, Aoshi, T, Tassi, I, Takai, T, Stanley, Sl, Miller, M, Shaw, A, Colonna, M.
سنة النشر: 2009
مصطلحات موضوعية: Macrophage survival, DAP12, beta-catenin
الوصف: Macrophage colony-stimulating factor (M-CSF) influences the proliferation and survival of mononuclear phagocytes through thereceptor CSF-1R. The adaptor protein DAP12 is critical for the unction of mononuclear phagocytes. DAP12-mutant mice and humans have defects in osteoclasts and microglia, as well as rain and bone abnormalities. Here we show DAP12 deficiency impaired the M-CSF-induced proliferation and survival of acrophages in vitro. DAP12-deficient mice had fewer microglia in defined central nervous system areas, and DAP12-deficient rogenitors regenerated myeloid cells inefficiently after bone arrow transplantation. Signaling by M-CSF through CSF-1R induced the stabilization and nuclear translocation of b-catenin, which activated genes involved in the cell cycle. DAP12 was essential for phosphorylation and nuclear accumulation of b-catenin. Our results provide a mechanistic explanation for the many defects of DAP12-deficient mononuclear phagocytes.
نوع الوثيقة: article in journal/newspaper
اللغة: English
Relation: info:eu-repo/semantics/altIdentifier/pmid/19503107; info:eu-repo/semantics/altIdentifier/wos/WOS:000267142600013; volume:10(7); firstpage:734; lastpage:743; numberofpages:10; journal:NATURE IMMUNOLOGY; https://hdl.handle.net/20.500.11768/162476
DOI: 10.1038/ni.1744
الاتاحة: https://hdl.handle.net/20.500.11768/162476
https://doi.org/10.1038/ni.1744
رقم الانضمام: edsbas.BFC8BA34
قاعدة البيانات: BASE