Academic Journal
Oncogenic Signaling Pathways in The Cancer Genome Atlas.
العنوان: | Oncogenic Signaling Pathways in The Cancer Genome Atlas. |
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المؤلفون: | Sanchez-Vega, F., Armenia, J., Chatila, W.K., Luna, A., La, K.C., Dimitriadoy, S., Liu, D.L., Kantheti, H.S., Saghafinia, S., Chakravarty, D., Daian, F., Gao, Q., Bailey, M.H., Liang, W.W., Foltz, S.M., Shmulevich, I., Ding, L., Heins, Z., Ochoa, A., Gross, B., Gao, J., Zhang, H., Kundra, R., Kandoth, C., Bahceci, I., Dervishi, L., Dogrusoz, U., Zhou, W., Shen, H., Laird, P.W., Way, G.P., Greene, C.S., Liang, H., Xiao, Y., Wang, C., Iavarone, A., Berger, A.H., Bivona, T.G., Lazar, A.J., Hammer, G.D., Giordano, T., Kwong, L.N., McArthur, G., Huang, C., Tward, A.D., Frederick, M.J., McCormick, F., Meyerson, M., Van Allen, E.M., Cherniack, A.D., Sander, C., Schultz, N. |
المساهمون: | Cancer Genome Atlas Research Network, Caesar-Johnson, S.J., Demchok, J.A., Felau, I., Kasapi, M., Ferguson, M.L., Hutter, C.M., Sofia, H.J., Tarnuzzer, R., Wang, Z., Yang, L., Zenklusen, J.C., Zhang, J.J., Chudamani, S., Liu, J., Lolla, L., Naresh, R., Pihl, T., Sun, Q., Wan, Y., Wu, Y., Cho, J., DeFreitas, T., Frazer, S., Gehlenborg, N., Getz, G., Heiman, D.I., Kim, J., Lawrence, M.S., Lin, P., Meier, S., Noble, M.S., Saksena, G., Voet, D., Zhang, H., Bernard, B., Chambwe, N., Dhankani, V., Knijnenburg, T., Kramer, R., Leinonen, K., Liu, Y., Miller, M., Reynolds, S., Shmulevich, I., Thorsson, V., Zhang, W., Akbani, R., Broom, B.M., Hegde, A.M., Ju, Z., Kanchi, R.S., Korkut, A., Li, J., Liang, H., Ling, S., Liu, W., Lu, Y., Mills, G.B., Ng, K.S., Rao, A., Ryan, M., Wang, J., Weinstein, J.N., Zhang, J., Abeshouse, A., Armenia, J., Chakravarty, D., Chatila, W.K., de Bruijn, I., Gao, J., Gross, B.E., Heins, Z.J., Kundra, R., La, K., Ladanyi, M., Luna, A., Nissan, M.G., Ochoa, A., Phillips, S.M., Reznik, E., Sanchez-Vega, F., Sander, C., Schultz, N., Sheridan, R., Sumer, S.O., Sun, Y., Taylor, B.S., Anur, P., Peto, M., Spellman, P., Benz, C., Stuart, J.M., Wong, C.K., Yau, C., Hayes, D.N., Parker, J.S., Wilkerson, M.D. |
المصدر: | Cell, vol. 173, no. 2, pp. 321-337.e10 |
سنة النشر: | 2018 |
المجموعة: | Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
مصطلحات موضوعية: | Databases, Genetic, Genes, Neoplasm, Humans, Neoplasms/genetics, Neoplasms/pathology, Phosphatidylinositol 3-Kinases/genetics, Phosphatidylinositol 3-Kinases/metabolism, Signal Transduction/genetics, Transforming Growth Factor beta/genetics, Transforming Growth Factor beta/metabolism, Tumor Suppressor Protein p53/genetics, Tumor Suppressor Protein p53/metabolism, Wnt Proteins/genetics, Wnt Proteins/metabolism, PanCanAtlas, TCGA, cancer genome atlas, cancer genomics, combination therapy, pan-cancer, precision oncology, signaling pathways, therapeutics, whole exome sequencing |
الوصف: | Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-occurrence of alterations in these pathways differ between individual tumors and tumor types. Using mutations, copy-number changes, mRNA expression, gene fusions and DNA methylation in 9,125 tumors profiled by The Cancer Genome Atlas (TCGA), we analyzed the mechanisms and patterns of somatic alterations in ten canonical pathways: cell cycle, Hippo, Myc, Notch, Nrf2, PI-3-Kinase/Akt, RTK-RAS, TGFβ signaling, p53 and β-catenin/Wnt. We charted the detailed landscape of pathway alterations in 33 cancer types, stratified into 64 subtypes, and identified patterns of co-occurrence and mutual exclusivity. Eighty-nine percent of tumors had at least one driver alteration in these pathways, and 57% percent of tumors had at least one alteration potentially targetable by currently available drugs. Thirty percent of tumors had multiple targetable alterations, indicating opportunities for combination therapy. |
نوع الوثيقة: | article in journal/newspaper |
وصف الملف: | application/pdf |
اللغة: | English |
Relation: | info:eu-repo/semantics/altIdentifier/pmid/29625050; info:eu-repo/semantics/altIdentifier/eissn/1097-4172; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_03A6331C652C4; https://serval.unil.ch/notice/serval:BIB_03A6331C652C; https://serval.unil.ch/resource/serval:BIB_03A6331C652C.P001/REF.pdf |
DOI: | 10.1016/j.cell.2018.03.035 |
الاتاحة: | https://serval.unil.ch/notice/serval:BIB_03A6331C652C https://doi.org/10.1016/j.cell.2018.03.035 https://serval.unil.ch/resource/serval:BIB_03A6331C652C.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_03A6331C652C4 |
Rights: | info:eu-repo/semantics/openAccess ; Copying allowed only for non-profit organizations ; https://serval.unil.ch/disclaimer |
رقم الانضمام: | edsbas.BF8AC770 |
قاعدة البيانات: | BASE |
DOI: | 10.1016/j.cell.2018.03.035 |
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