Academic Journal
Short-peptide supramolecular hydrogels for in situ growth of metal-organic framework-peptide biocomposites
| العنوان: | Short-peptide supramolecular hydrogels for in situ growth of metal-organic framework-peptide biocomposites |
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| المؤلفون: | Illescas-López, S., Martin-Romera, Javier D., Mañas-Torres, Mari C., Lopez-Lopez, Modesto T., Cuerva, Juan M., Gavira Gallardo, J. A., Carmona, Francisco J., Álvarez de Cienfuegos, Luis |
| المساهمون: | Ministerio de Ciencia e Innovación (España), European Commission, Universidad de Granada |
| بيانات النشر: | American Chemical Society |
| سنة النشر: | 2023 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| مصطلحات موضوعية: | Biocomposites, Composite materials, Metal−organic frameworks, Short peptides, Supramolecular hydrogels |
| الوصف: | The development of bio-MOFs or MOF biocomposites through the combination of MOFs with biopolymers offers the possibility of expanding the potential applications of MOFs, making use of more environmentally benign processes and reagents and giving rise to a new generation of greener and more bio-oriented composite materials. Now, with the increasing use of MOFs for biotechnological applications, the development of new protocols and materials to obtain novel bio-MOFs compatible with biomedical or biotechnological uses is needed. Herein, and as a proof of concept, we have explored the possibility of using short-peptide supramolecular hydrogels as media to promote the growth of MOF particles, giving rise to a new family of bio-MOFs. Short-peptide supramolecular hydrogels are very versatile materials that have shown excellent in vitro and in vivo biomedical applications such as tissue engineering and drug delivery vehicles, among others. These peptides self-assemble by noncovalent interactions, and, as such, these hydrogels are easily reversible, being more biocompatible and biodegradable. These peptides can self-assemble by a multitude of stimuli, such as changes in pH, temperature, solvent, adding salts, enzymatic activity, and so forth. In this work, we have taken advantage of this ability to promote peptide self-assembly with some of the components required to form MOF particles, giving rise to more homogeneous and well-integrated composite materials. Hydrogel formation has been triggered using Zn salts, required to form ZIF-8, and formic acid, required to form MOF-808. Two different protocols for the in situ MOF growth have been developed. Finally, the MOF-808 composite hydrogel has been tested for the decontamination of water polluted with phosphate ions as well as for the catalytic degradation of toxic organophosphate methyl paraoxon in an unbuffered solution. ; This study was supported by grants PID2020-118498GB-I00 and PID2020-113608RB-I00 funded by MCIN/AEI/10.13039/501100011033, projects P18-FR-3533 and ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 1944-8252 |
| Relation: | #PLACEHOLDER_PARENT_METADATA_VALUE#; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-118498GB-I00/ES/MAQUINAS BASADAS EN HIDROGELES BIOCOMPATIBLES PROGRAMADOS MAGNETICAMENTE/; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-113608RB-I00/ES/MATERIALES METAL-ORGANICOS POROSOS PARA LA DESCONTAMINACION Y DETOXIFICACION DE COMPUESTOS DE FOSFORO/; Publisher's version; http://dx.doi.org/10.1021/acsami.3c06943; Sí; ACS Applied Materials and Interfaces 15: 32597-32609 (2023); http://hdl.handle.net/10261/346792 |
| DOI: | 10.1021/acsami.3c06943 |
| الاتاحة: | http://hdl.handle.net/10261/346792 https://doi.org/10.1021/acsami.3c06943 |
| Rights: | open |
| رقم الانضمام: | edsbas.BF84FB8C |
| قاعدة البيانات: | BASE |
| تدمد: | 19448252 |
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| DOI: | 10.1021/acsami.3c06943 |