Academic Journal
Differences in neutralizing antibody sensitivities and envelope characteristics indicate distinct antigenic properties of Nigerian HIV-1 subtype G and CRF02_AG
| العنوان: | Differences in neutralizing antibody sensitivities and envelope characteristics indicate distinct antigenic properties of Nigerian HIV-1 subtype G and CRF02_AG |
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| المؤلفون: | Lindsay Wieczorek, David Chang, Eric Sanders-Buell, Michelle Zemil, Elizabeth Martinez, Jesse Schoen, Agnes-Laurence Chenine, Sebastian Molnar, Brittani Barrows, Kultida Poltavee, Man E. Charurat, Alash’le Abimiku, William Blattner, Michael Iroezindu, Afoke Kokogho, Nelson L. Michael, Trevor A. Crowell, Julie A. Ake, Sodsai Tovanabutra, Victoria R. Polonis |
| المصدر: | Virology Journal, Vol 21, Iss 1, Pp 1-14 (2024) |
| بيانات النشر: | BMC |
| سنة النشر: | 2024 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | HIV, Envelope (Env), Antibody, Nigeria, West Africa, Subtype G, Infectious and parasitic diseases, RC109-216 |
| الوصف: | The magnitude of the HIV-1 epidemic in Nigeria is second only to the subtype C epidemic in South Africa, yet the subtypes prevalent in Nigeria require further characterization. A panel of 50 subtype G and 18 CRF02_AG Nigerian HIV-1 pseudoviruses (PSV) was developed and envelope coreceptor usage, neutralization sensitivity and cross-clade reactivity were characterized. These PSV were neutralized by some antibodies targeting major neutralizing determinants, but potentially important differences were observed in specific sensitivities (eg. to sCD4, MPER and V2/V3 monoclonal antibodies), as well as in properties such as variable loop lengths, number of potential N-linked glycans and charge, demonstrating distinct antigenic characteristics of CRF02_AG and subtype G. There was preferential neutralization of the matched CRF/subtype when PSV from subtype G or CRF02_AG were tested using pooled plasma. These novel Nigerian PSV will be useful to study HIV-1 CRF- or subtype-specific humoral immune responses for subtype G and CRF02_AG. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1743-422X |
| Relation: | https://doi.org/10.1186/s12985-024-02394-y; https://doaj.org/toc/1743-422X; https://doaj.org/article/ddfeaaa90c034894b2a7019be230a0b6 |
| DOI: | 10.1186/s12985-024-02394-y |
| الاتاحة: | https://doi.org/10.1186/s12985-024-02394-y https://doaj.org/article/ddfeaaa90c034894b2a7019be230a0b6 |
| رقم الانضمام: | edsbas.BF7B66A8 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 1743422X |
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| DOI: | 10.1186/s12985-024-02394-y |