Academic Journal
PML Nuclear bodies: the cancer connection and beyond
| العنوان: | PML Nuclear bodies: the cancer connection and beyond |
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| المؤلفون: | Abou-Ghali, Majdouline, Lallemand-Breitenbach, Valérie |
| المساهمون: | Centre interdisciplinaire de recherche en biologie (CIRB), Labex MemoLife, École normale supérieure - Paris (ENS-PSL), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris Sciences et Lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris Sciences et Lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM), ITMO Cancer PCSI (C22028DS, VLB), Collège de France, INSERM, CNRS, Université de Paris, Labex Memolife (VLB), Fondation du Collège de France, European Research Council Advanced Grant 785917–PML-THERAPY (to H.d.T.) |
| المصدر: | ISSN: 1949-1034 ; Nucleus ; https://hal.science/hal-04772294 ; Nucleus, 2024, 15 (1), ⟨10.1080/19491034.2024.2321265⟩ ; https://doi.org/10.1080/19491034.2024.2321265. |
| بيانات النشر: | CCSD Taylors and Francis |
| سنة النشر: | 2024 |
| المجموعة: | ESPCI ParisTech: HAL (Ecole Supérieure de Physique et Chimie Industrielles) |
| مصطلحات موضوعية: | Nuclear bodies, oxidative stress, PML, post-translational modifications, senescence, SUMO, transcription, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Promyelocytic leukemia (PML) nuclear bodies, membrane-less organelles in the nucleus, play a crucial role in cellular homeostasis. These dynamic structures result from the assembly of scaffolding PML proteins and various partners. Recent crystal structure analyses revealed essential self-interacting domains, while liquid–liquid phase separation contributes to their formation. PML bodies orchestrate post-translational modifications, particularly stress-induced SUMOylation, impacting target protein functions. Serving as hubs in multiple signaling pathways, they influence cellular processes like senescence. Dysregulation of PML expression contributes to diseases, including cancer, highlighting their significance. Therapeutically, PML bodies are promising targets, exemplified by successful acute promyelocytic leukemia treatment with arsenic trioxide and retinoic acid restoring PML bodies. Understanding their functions illuminates both normal and pathological cellular physiology, guiding potential therapies. This review explores recent advancements in PML body biogenesis, biochemical activity, and their evolving biological roles. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1080/19491034.2024.2321265 |
| الاتاحة: | https://hal.science/hal-04772294 https://hal.science/hal-04772294v1/document https://hal.science/hal-04772294v1/file/PML%20Nuclear%20bodies%20the%20cancer%20connection%20and%20beyond.pdf https://doi.org/10.1080/19491034.2024.2321265 |
| Rights: | http://creativecommons.org/licenses/by-nc/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.BF73D0AD |
| قاعدة البيانات: | BASE |
| DOI: | 10.1080/19491034.2024.2321265 |
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