Academic Journal
In vivo assessment of marine vs bovine origin collagen-based composite scaffolds promoting bone regeneration in a New Zealand rabbit model
| العنوان: | In vivo assessment of marine vs bovine origin collagen-based composite scaffolds promoting bone regeneration in a New Zealand rabbit model |
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| المؤلفون: | Diogo, Gabriela S., Permuy, María, Marques, Catarina F., González Sotelo, Carmen, Pérez Martín, Ricardo Isaac, Serra, Julia, González, Pio, Muñoz, Fernando, Pirraco, Rogério P., Reis, Rui L., Silva, Tiago H. |
| المساهمون: | Fundação para a Ciência e a Tecnologia (Portugal), European Commission, Diogo, Gabriela S., Permuy, María, González Sotelo, Carmen, Pérez Martín, Ricardo Isaac, Muñoz, Fernando |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2024 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| مصطلحات موضوعية: | Fish collagen, Apatite, Blue shark, Bone regeneration, New Zealand rabbit, Marine biomaterials, http://aims.fao.org/aos/agrovoc/c_1755, http://aims.fao.org/aos/agrovoc/c_5bbf486b, http://aims.fao.org/aos/agrovoc/c_7028, collagen, sharks |
| الوصف: | 13 pages, 8 figures.-- Under a Creative Commons license ; The ability of human tissues to self-repair is limited, which motivates the scientific community to explore new and better therapeutic approaches to tissue regeneration. The present manuscript provides a comparative study between a marine-based composite biomaterial, and another composed of well-established counterparts for bone tissue regeneration. Blue shark skin collagen was combined with bioapatite obtained from blue shark's teeth (mColl:BAp), while bovine collagen was combined with synthetic hydroxyapatite (bColl:Ap) to produce 3D composite scaffolds by freeze-drying. Collagens showed similar profiles, while apatite particles differed in their composition, being the marine bioapatite a fluoride-enriched ceramic. The marine-sourced biomaterials presented higher porosities, improved mechanical properties, and slower degradation rates when compared to synthetic apatite-reinforced bovine collagen. The in vivo performance regarding bone tissue regeneration was evaluated in defects created in femoral condyles in New Zealand rabbits twelve weeks post-surgery. Micro-CT results showed that mColl:BAp implanted condyles had a slower degradation and an higher tissue formation (17.9 ± 6.9 %) when compared with bColl:Ap implanted ones (12.9 ± 7.6 %). The histomorphometry analysis provided supporting evidence, confirming the observed trend by quantifying 13.1 ± 7.9 % of new tissue formation for mColl:BAp composites and 10.4 ± 3.2 % for bColl:Ap composites, suggesting the potential use of marine biomaterials for bone regeneration ; This study was funded by the Portuguese Foundation for Science and Technology (FCT) under the scope of the BiogenInk project (M-ERA-NET2/0022/2016), by European Regional Development Fund through INTERREG Spain-Portugal Programme, under the scope of 0245_IBEROS_1_E project, through INTERREG Atlantic Area Programme, under the scope of BLUEHUMAN (EAPA_151/2016) project and through Northern Portugal Regional Operational Program (NORTE 2020), ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2772-9508 |
| Relation: | Publisher's version; No data was used for the research described in the article; https://doi.org/10.1016/j.bioadv.2024.213813; Sí; Biomaterials Advances 159: 213813 (2024); http://hdl.handle.net/10261/350682 |
| DOI: | 10.1016/j.bioadv.2024.213813 |
| الاتاحة: | http://hdl.handle.net/10261/350682 https://doi.org/10.1016/j.bioadv.2024.213813 |
| Rights: | open |
| رقم الانضمام: | edsbas.BF56D696 |
| قاعدة البيانات: | BASE |
| تدمد: | 27729508 |
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| DOI: | 10.1016/j.bioadv.2024.213813 |