التفاصيل البيبلوغرافية
| العنوان: |
Pivotal Role for Cxcr2 in Regulating Tumor-Associated Neutrophil in Breast Cancer |
| المؤلفون: |
Colin Timaxian, Christoph F. A. Vogel, Charlotte Orcel, Diana Vetter, Camille Durochat, Clarisse Chinal, Phuong NGuyen, Marie-Laure Aknin, Françoise Mercier-Nomé, Martin Davy, Isabelle Raymond-Letron, Thi-Nhu-Ngoc Van, Sarah D. Diermeier, Anastasia Godefroy, Magali Gary-Bobo, Franck Molina, Karl Balabanian, Gwendal Lazennec |
| المصدر: |
Cancers; Volume 13; Issue 11; Pages: 2584 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2021 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
chemokine receptors, breast cancer, Cxcr2, neutrophils, tumor microenvironment |
| الوصف: |
Chemokines present in the tumor microenvironment are essential for the control of tumor progression. We show here that several ligands of the chemokine receptor Cxcr2 were up-regulated in the PyMT (polyoma middle T oncogene) model of breast cancer. Interestingly, the knock-down of Cxcr2 in PyMT animals led to an increased growth of the primary tumor and lung metastasis. The analysis of tumor content of PyMT-Cxcr2−/− animals highlighted an increased infiltration of tumor associated neutrophils (TANs), mirrored by a decreased recruitment of tumor associated macrophages (TAMs) compared to PyMT animals. Analysis of PyMT-Cxcr2−/− TANs revealed that they lost their killing ability compared to PyMT-Cxcr2+/+ TANs. The transcriptomic analysis of PyMT-Cxcr2−/− TANs showed that they had a more pronounced pro-tumor TAN2 profile compared to PyMT TANs. In particular, PyMT-Cxcr2−/− TANs displayed an up-regulation of the pathways involved in reactive oxygen species (ROS) production and angiogenesis and factors favoring metastasis, but reduced apoptosis. In summary, our data reveal that a lack of Cxcr2 provides TANs with pro-tumor effects. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Tumor Microenvironment; https://dx.doi.org/10.3390/cancers13112584 |
| DOI: |
10.3390/cancers13112584 |
| الاتاحة: |
https://doi.org/10.3390/cancers13112584 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.BF429F66 |
| قاعدة البيانات: |
BASE |