Academic Journal
A Computational Approach Using Bioinformatics to Screening Drug Targets for Leishmania infantum Species
| العنوان: | A Computational Approach Using Bioinformatics to Screening Drug Targets for Leishmania infantum Species |
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| المؤلفون: | Chávez-Fumagalli, Miguel Angel, Schneider, Mônica Santos, Lage, Daniela Pagliara, Tavares, Grasiele de Sousa Vieira, Mendonça, Débora Vasconcelos Costa, Santos, Thaís Teodoro de Oliveira, Pádua, Rodrigo Maia, Machado-de-Ávila, Ricardo Andrez, Leite, João Paulo Viana, Coelho, Eduardo Antonio Ferraz |
| المساهمون: | De Tommasi, Nunziatina, Pró-Reitoria de Pesquisa, Universidade Federal de Minas Gerais, Fundação de Amparo à Pesquisa do Estado de Minas Gerais, Conselho Nacional de Desenvolvimento Científico e Tecnológico |
| المصدر: | Evidence-Based Complementary and Alternative Medicine ; volume 2018, issue 1 ; ISSN 1741-427X 1741-4288 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2018 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Background . The development of new therapeutic strategies to treat patients for leishmaniasis has become a priority. The antileishmanial activity of the strychnobiflavone flavonoid was recently demonstrated against Leishmania amazonensis and Leishmania infantum amastigotes and promastigotes. The biological effect of this molecule was identified due to its capacity to interfere in the parasite mitochondrial membrane; however, the underlying molecular mechanism remains unclear. Methods and Results . In this study, a computational approach using bioinformatics was performed to screen biological targets of strychnobiflavone in L. infantum . Computational programs, such as the target fishing approach and molecular docking assays, were used. Results showed that the putative pathway targeted by strychnobiflavone in L. infantum is the methylglyoxal degradation superpathway, and one hydrolase‐like protein was predicted to be the molecular target of this flavonoid in the parasites. Conclusion . In this context, this study provides the basis for understanding the mechanism of action of strychnobiflavone in L. infantum and presents a strategy based on bioinformatics programs to screen targets of other molecules with biological action against distinct pathogens. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1155/2018/6813467 |
| الاتاحة: | http://dx.doi.org/10.1155/2018/6813467 http://downloads.hindawi.com/journals/ecam/2018/6813467.pdf http://downloads.hindawi.com/journals/ecam/2018/6813467.xml https://onlinelibrary.wiley.com/doi/pdf/10.1155/2018/6813467 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.BEFC2101 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1155/2018/6813467 |
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