Academic Journal
Candidemia in Adult Patients in the ICU: A Reappraisal of Susceptibility Testing and Antifungal Therapy
| العنوان: | Candidemia in Adult Patients in the ICU: A Reappraisal of Susceptibility Testing and Antifungal Therapy |
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| المؤلفون: | Chastain, Daniel B., White, Bryan P., Tu, Patrick J., Chan, Sophea, Jackson, Brittany T., Kubbs, Kara A., Bandali, Aiman, McDougal, Steven, Henao-Martínez, Andrés F., Cluck, David B. |
| المصدر: | Annals of Pharmacotherapy ; volume 58, issue 3, page 305-321 ; ISSN 1060-0280 1542-6270 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2023 |
| الوصف: | Objective: To provide updates on the epidemiology and recommendations for management of candidemia in patients with critical illness. Data Sources: A literature search using the PubMed database (inception to March 2023) was conducted using the search terms “invasive candidiasis,” “candidemia,” “critically ill,” “azoles,” “echinocandin,” “antifungal agents,” “rapid diagnostics,” “antifungal susceptibility testing,” “therapeutic drug monitoring,” “antifungal dosing,” “persistent candidemia,” and “Candida biofilm.” Study Selection/Data Extraction: Clinical data were limited to those published in the English language. Ongoing trials were identified through ClinicalTrials.gov. Data Synthesis: A total of 109 articles were reviewed including 25 pharmacokinetic/pharmacodynamic studies and 30 studies including patient data, 13 of which were randomized controlled clinical trials. The remaining 54 articles included fungal surveillance data, in vitro studies, review articles, and survey data. The current 2016 Infectious Diseases Society of America (IDSA) Clinical Practice Guideline for the Management of Candidiasis provides recommendations for selecting empiric and definitive antifungal therapies for candidemia, but data are limited regarding optimized dosing strategies in critically ill patients with dynamic pharmacokinetic changes or persistent candidemia complicated. Relevance to Patient Care and Clinical Practice: Outcomes due to candidemia remain poor despite improved diagnostic platforms, antifungal susceptibility testing, and antifungal therapy selection for candidemia in critically ill patients. Earlier detection and identification of the species causing candidemia combined with recognition of patient-specific factors leading to dosing discrepancies are crucial to improving outcomes in critically ill patients with candidemia. Conclusions: Treatment of candidemia in critically ill patients must account for the incidence of non-albicans Candida species and trends in antifungal resistance as well as overcome the ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1177/10600280231175201 |
| الاتاحة: | http://dx.doi.org/10.1177/10600280231175201 http://journals.sagepub.com/doi/pdf/10.1177/10600280231175201 http://journals.sagepub.com/doi/full-xml/10.1177/10600280231175201 |
| Rights: | https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| رقم الانضمام: | edsbas.BEF920BC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/10600280231175201 |
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