Dissertation/ Thesis
Toll-like Receptors - Link between Innate and Adaptive Immunity ; Toll-ähnliche Rezeptoren - Mittler zwischen angeborener und erworbener Immunität
| العنوان: | Toll-like Receptors - Link between Innate and Adaptive Immunity ; Toll-ähnliche Rezeptoren - Mittler zwischen angeborener und erworbener Immunität |
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| المؤلفون: | Braedel-Ruoff, Sibylla |
| المساهمون: | Rammensee, Hans-Georg (Prof. Dr.) |
| بيانات النشر: | Universität Tübingen |
| سنة النشر: | 2007 |
| المجموعة: | Eberhard Karls University Tübingen: Publication System |
| مصطلحات موضوعية: | Toll-like-Rezeptoren, Hitzeschock-Proteine, Aspergillose, Legionella pneumophila, Immunität |
| Time: | 540 |
| الوصف: | Summary: Toll-like receptors (TLR) function as pattern recognition receptors (PRR) and recognize highly conserved pathogen-associated molecular patterns. They not only activate an immediate innate immune defense but are additionally able to induce an adaptive immune response. The questions, which substances are recognized via TLRs, which specific TLRs are involved by a given danger signal and which mechanisms finally lead to the activation of the adaptive immune system, were the focus of this thesis. Investigation of the bacteria Legionella pneumophila, the causative agent of Legionnaires' disease, revealed that lipopolysaccharide (LPS) purified from the cell wall as well as the whole bacteria activate antigen-presenting cells (APC) via TLR2-dependent signal transduction. Thus, LPS was identified as the main structure for the recognition of L. pneumophila by the innate immune system (Chapter 2). Furthermore, TLRs play a central role in the activation of the innate immune system by antigens of the fungus A. fumigatus, which causes invasive aspergillosis. Thereby, the involvement of TLR2 and TLR4 results in the release of different pro-inflammatory cytokines by APCs (Chapter 3). TLRs, however, do not only recognize exogenous pathogen-derived molecules, but also endogenous alarm structures. This could be demonstrated for the ER-resident heat shock protein Gp96, which, as carrier of tumor-specific peptides, is able to elicit protective immunity against tumors. The Gp96-induced activation of dendritic cells via TLR4 and TLR2 (Chapter 4) finally leads to the expansion of antigen-specific CD8-positive T cells in vivo and in vitro (Chapter 5). The relevance of TLR-mediated activation of the immune system for the induction of adaptive immune responses could also be demonstrated in a more general system: 'priming' of cytotoxic T cells (CLTs) during a virus infection requires either CD4+ T helper cells or TLR-mediated signals. In the absence of both, CTL priming is impaired. In a system of weaker immunogenic antigens, TLR ... |
| نوع الوثيقة: | doctoral or postdoctoral thesis |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | 275372529; http://nbn-resolving.de/urn:nbn:de:bsz:21-opus-27767; http://hdl.handle.net/10900/43863 |
| الاتاحة: | http://hdl.handle.net/10900/43863 http://nbn-resolving.de/urn:nbn:de:bsz:21-opus-27767 |
| Rights: | ubt-podok ; http://tobias-lib.uni-tuebingen.de/doku/lic_mit_pod.php?la=de ; http://tobias-lib.uni-tuebingen.de/doku/lic_mit_pod.php?la=en |
| رقم الانضمام: | edsbas.BEEBD169 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |