التفاصيل البيبلوغرافية
| العنوان: |
Antigenic phenotypes of Escherichia coli isolated in urinary tract infections and the effect of these antigens against host defense function ; 尿路感染症起炎大腸菌の表現型と大腸菌諸抗原の生体に及ぼす影響 |
| المؤلفون: |
森口, 直彦, モリグチ, ナオヒコ |
| بيانات النشر: |
近畿大学 |
| سنة النشر: |
1992 |
| المجموعة: |
Kindai University Academic Resource Repository / 近畿大学学術情報リポジトリ |
| مصطلحات موضوعية: |
urinary tract infection, P-fimbriae, O antigen, K1 antigen, host defense function |
| الوصف: |
[ABSTRACT] We analyzed the relationship between the antigenic phenotypes of E. coli and clinical diagnosis, and the interaction between the bacterial antigens and host defense function. E. coli which possessed the O1 antigen were isolated more frequently from patients with acute and chronic pyelonephritis than from the normal controls (p ＜0.05). K1 positive or P-fimbriae (P-0f) positive E. coli were more frequently found in urine from patients with acute pyelonephritis than in the normal controls (either p ＜ 0.005). E. coli which possessed the O1 antigen, tended to exhibit P-f. Analysis of the immune bacteriolytic activities by normal pooled sera showed that the K 1 positive strains were more resistant than the standard strain. However, there was no relationship between the degree of the phagocytosed bacteria by normal poly-morphonuclear leukocyte (PMN) and the kind of O- or K- antigen. To compare the stimulative activity of the bacterial antigens against the PMN's chemiluminescence (C. L.), various kinds of O antigen and K antigen were extracted from these E. coli. Antigen O44, from the enteropathogenic E. coli (EPEC) and O1 from the pyelonephritopathogenic strain stimulated normal PMN more significantly and showed a higher peak C. L. than the other kinds of O antigen (p ＜ 0.05). Antigen K74 from EPEC and K1 from a pyelonephritopathogenic strain revealed a higher stimulative effect than antigen K7 from the standard strain (p ＜ 0.01). These findings indicate that the pyelonephritopathogenic strains belong to a small number of clones, and that these strains produce more severe inflamatory lesions ; 学位の種類：医学 学位授与年月日：1992/6/15 指導: 牧, 淳 教授(Director : Prof. Maki, Sunao) 報告番号：乙第171号 学内授与番号：医乙122 NDL書誌ID：000000266541 ; application/pdf ; thesis |
| نوع الوثيقة: |
other/unknown material |
| وصف الملف: |
application/pdf |
| اللغة: |
Japanese |
| Relation: |
博士学位論文; 34; Thesis or Dissertation; https://kindai.repo.nii.ac.jp/record/2127/files/Thesis_Meo0122-19920615-0001.pdf |
| الاتاحة: |
https://kindai.repo.nii.ac.jp/record/2127/files/Thesis_Meo0122-19920615-0001.pdf |
| رقم الانضمام: |
edsbas.BEE08ABE |
| قاعدة البيانات: |
BASE |