التفاصيل البيبلوغرافية
| العنوان: |
Cystatin-c May Indicate Subclinical Renal Involvement, While Orosomucoid Is Associated with Fatigue in Patients with Long-COVID Syndrome |
| المؤلفون: |
Laszlo Zavori, Tihamer Molnar, Reka Varnai, Andrea Kanizsai, Lajos Nagy, Bence Vadkerti, Balazs Szirmay, Attila Schwarcz, Peter Csecsei |
| المصدر: |
Journal of Personalized Medicine; Volume 13; Issue 2; Pages: 371 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2023 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
long-COVID syndrome, cystatin-c, orosomucoid, l-arginine, symmetric dimethylarginine, fatigue, renal function |
| الوصف: |
Long-COVID syndrome is associated with high healthcare costs, but its pathophysiology is not yet fully understood. Inflammation, renal impairment or disturbance of the NO system emerge as potential pathogenetic factors. We aimed to investigate the relationship between symptoms of long-COVID syndrome and serum levels of cystatin-c (CYSC), orosomucoid (ORM), l-arginine, symmetric dimethylarginine (SDMA) and asymmetric dimethylarginine (ADMA). A total of 114 patients suffering from long-COVID syndrome were included in this observational cohort study. We found that serum CYSC was independently associated with the anti-spike immunoglobulin (S-Ig) serum level (OR: 5.377, 95% CI: 1.822–12.361; p = 0.02), while serum ORM (OR: 9.670 (95% CI: 1.34–9.93; p = 0.025) independently predicted fatigue in patients with long-COVID syndrome, both measured at baseline visit. Additionally, the serum CYSC concentrations measured at the baseline visit showed a positive correlation with the serum SDMA levels. The severity of abdominal and muscle pain indicated by patients at the baseline visit showed a negative correlation with the serum level of L-arginine. In summary, serum CYSC may indicate subclinical renal impairment, while serum ORM is associated with fatigue in long-COVID syndrome. The potential role of l-arginine in alleviating pain requires further studies. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Mechanisms of Diseases; https://dx.doi.org/10.3390/jpm13020371 |
| DOI: |
10.3390/jpm13020371 |
| الاتاحة: |
https://doi.org/10.3390/jpm13020371 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.BED74089 |
| قاعدة البيانات: |
BASE |