Academic Journal
Macrophage tropism of human immunodeficiency virus type 1 facilitates in vivo escape from cytotoxic T-lymphocyte pressure.
| العنوان: | Macrophage tropism of human immunodeficiency virus type 1 facilitates in vivo escape from cytotoxic T-lymphocyte pressure. |
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| المؤلفون: | Schutten, M. (Martin), Baalen, C.A. (Carel) van, Guillon, C. (Christophe), Huisman, R.C. (Robin), Boers, P.H.M. (Patrick), Sintnicolaas, K. (Krijn), Gruters, R.A. (Rob), Osterhaus, A.D.M.E. (Albert) |
| المصدر: | Journal of Virology vol. 75 no. 6, pp. 2706-2709 |
| سنة النشر: | 2001 |
| المجموعة: | RePub - Publications from Erasmus University, Rotterdam |
| مصطلحات موضوعية: | Animals, Disease Models, Animal, Gene Products, rev/immunology, Graft vs Host Disease/immunology/virology, HIV Infections/immunology/*virology, HIV-1/genetics/*physiology, Humans, Leukocytes, Mononuclear/virology, Macrophages/*virology, Mice, Inbred CBA, Mutation, Research Support, Non-U.S. Gov't, T-Lymphocytes, Cytotoxic/*immunology, Virus Replication |
| الوصف: | Early after seroconversion, macrophage-tropic human immunodeficiency virus type 1 (HIV-1) variants are predominantly found, even when a mixture of macrophage-tropic and non-macrophage-tropic variants was transmitted. For virus contracted by sexual transmission, this is presently explained by selection at the port of entry, where macrophages are infected and T cells are relatively rare. Here we explore an additional mechanism to explain the selection of macrophage-tropic variants in cases where the mucosa is bypassed during transmission, such as blood transfusion, needle-stick accidents, or intravenous drug abuse. With molecularly cloned primary isolates of HIV-1 in irradiated mice that had been reconstituted with a high dose of human peripheral blood mononuclear cells, we found that a macrophage-tropic HIV-1 clone escaped more efficiently from specific cytotoxic T-lymphocyte (CTL) pressure than its non-macrophage-tropic counterpart. We propose that CTLs favor the selective outgrowth of macrophage-tropic HIV-1 variants because infected macrophages are less susceptible to CTL activity than infected T cells. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | http://repub.eur.nl/pub/12918; urn:hdl:1765/12918 |
| DOI: | 10.1128/JVI.75.6.2706-2709.2001 |
| الاتاحة: | http://repub.eur.nl/pub/12918 https://doi.org/10.1128/JVI.75.6.2706-2709.2001 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.BE952E5C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1128/JVI.75.6.2706-2709.2001 |
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