Academic Journal
Aortic stiffness after living kidney donation: a systematic review and meta-analysis
| العنوان: | Aortic stiffness after living kidney donation: a systematic review and meta-analysis |
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| المؤلفون: | Rodriguez, Rosendo A, McNeill, Kylie, Agharazii, Mohsen, Bugeja, Ann, Clark, Edward G, Burns, Kevin D |
| المصدر: | BMJ Open ; volume 14, issue 12, page e082725 ; ISSN 2044-6055 2044-6055 |
| بيانات النشر: | BMJ |
| سنة النشر: | 2024 |
| الوصف: | Objectives Increased aortic stiffness measured with carotid-femoral pulse wave velocity (cf-PWV) has been associated with adverse cardiovascular outcomes. Some studies have reported increased cf-PWV in living kidney donors after nephrectomy. This review aimed to determine the effects of living kidney donation on cf-PWV, glomerular filtration rate (GFR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and their differences versus non-nephrectomised healthy individuals. Design Systematic review and meta-analysis. Data sources Electronic databases (MEDLINE, EMBASE, Cochrane Central databases, Cochrane Register of Controlled Trials, Cochrane Methodology Register, Health Technology Database, Technologies in Health, EBM Reviews, ProQuest and ‘Grey Matters Light’). Databases were searched from inception to December 2022. Eligibility criteria We searched for studies that measured cf-PWV in living kidney donors before and/or after nephrectomy. Non-nephrectomised healthy individuals included as controls were the comparators. Studies that provided age-adjusted cf-PWV reference values in normotensive healthy individuals were also included. Outcome measures We evaluated the mean differences in cf-PWV, GFR and BP before-and-after nephrectomy and their mean differences versus non-nephrectomised healthy comparators. We also explored differences in yearly adjusted cf-PWV changes between donors and normotensive healthy individuals. Data extraction/synthesis Two independent reviewers extracted data and assessed risk of bias (Risk of Bias tool for non-Randomised studies: ROBINS-I) and quality of evidence (GRADE). Pooled effect estimates were calculated using the inverse variance method and analysed with random effect models. Results Nine interventional (652 donors; 602 controls) and 6 reference studies (6278 individuals) were included. cf-PWV increased at 1-year postdonation (p=0.03) and was on average 0.4 m/s (95% CI 0.07; 0.60) higher than in healthy controls (p=0.01). These differences were non-significant 5 years ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1136/bmjopen-2023-082725 |
| الاتاحة: | https://doi.org/10.1136/bmjopen-2023-082725 https://syndication.highwire.org/content/doi/10.1136/bmjopen-2023-082725 |
| Rights: | http://creativecommons.org/licenses/by-nc/4.0/ |
| رقم الانضمام: | edsbas.BE5F2EEF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/bmjopen-2023-082725 |
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