Academic Journal
In vitro comparison of bradykinin degradation by aliskiren, a renin inhibitor, and an inhibitor of angiotensin-converting enzyme
| العنوان: | In vitro comparison of bradykinin degradation by aliskiren, a renin inhibitor, and an inhibitor of angiotensin-converting enzyme |
|---|---|
| المؤلفون: | Kusumam Joseph, Tracy E Tholanikunnel, Allen P Kaplan |
| المصدر: | Journal of the Renin-Angiotensin-Aldosterone System, Vol 16 (2015) |
| بيانات النشر: | Hindawi - SAGE Publishing |
| سنة النشر: | 2015 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Medicine (General), R5-920 |
| الوصف: | Introduction: Angiotensin-converting enzyme (ACE) inhibitors cause angioedema due to diminished degradation of bradykinin. Angiotensin receptor blockers may occasionally cause angioedema but the mechanism is unknown, and are generally considered safe, even in those who have reacted to ACE inhibitors. We determined whether aliskiren, a renin inhibitor, has an effect on the rate of bradykinin degradation. Methods: The ability of renin to metabolize bradykinin was studied and the rate of bradykinin degradation compared in the presence or absence of aliskiren. Enalapril, a known ACE inhibitor that causes angioedema served as positive control. Results: Renin was unable to digest bradykinin, indicating that a renin inhibitor is unlikely to affect the rate of bradykinin degradation. In a plasma system, aliskiren had no effect on the rate of bradykinin degradation while enalapril inhibited it appreciably. An inhibitory effect of aliskiren on the rate of bradykinin degradation by human pulmonary endothelial cells was observed, estimated to be about 5% of that of enalapril. Conclusion: Aliskiren has no effect upon the rate of bradykinin degradation in plasma and a minimal effect employing vascular endothelial cells. The latter suggests inhibition of a non-renin enzyme that is a minor contributor to bradykinin degradation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1470-3203 1752-8976 |
| Relation: | https://doi.org/10.1177/1470320313491997; https://doaj.org/toc/1470-3203; https://doaj.org/toc/1752-8976; https://doaj.org/article/afa7a747cac646c2a83417fcf9e0f00b |
| DOI: | 10.1177/1470320313491997 |
| الاتاحة: | https://doi.org/10.1177/1470320313491997 https://doaj.org/article/afa7a747cac646c2a83417fcf9e0f00b |
| رقم الانضمام: | edsbas.BDCF95AE |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14703203 17528976 |
|---|---|
| DOI: | 10.1177/1470320313491997 |