Academic Journal
Could propranolol be beneficial in adult cerebral cavernous malformations?
| العنوان: | Could propranolol be beneficial in adult cerebral cavernous malformations? |
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| المؤلفون: | Apra, Caroline, Dumot, Chloé, Bourdillon, Pierre, Pelissou-Guyotat, Isabelle |
| المساهمون: | Sorbonne Université - Faculté de Médecine (SU FM), Sorbonne Université (SU), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Hospices Civils de Lyon (HCL), Hôpital neurologique et neurochirurgical Pierre Wertheimer CHU - HCL, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon |
| المصدر: | ISSN: 0344-5607. |
| بيانات النشر: | CCSD Springer Verlag |
| سنة النشر: | 2019 |
| المجموعة: | HAL Lyon 1 (University Claude Bernard Lyon 1) |
| مصطلحات موضوعية: | Beta-blocker, Cavernomas, Cavernous angiomas, Cavernous haemangiomas, Cavernous malformations, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology |
| الوصف: | International audience ; Surgery is the only therapeutic option for cerebral cavernous malformations (CCM) and is proposed, whenever possible, after haemorrhagic events, neurological symptoms, or epilepsy, radiosurgery being a controversial alternative in some cases. However, there is no treatment for non-accessible lesions, such as brainstem CCM, multiple CCM, or those located in functional areas. Propranolol, a non-selective beta-blocker used as first-line treatment for infantile haemangiomas, has proved spectacularly effective in a few cases of adult patients with CCM. We herein review the histological, in vitro data and clinical findings that support the idea of propranolol as a potential treatment for CCM. Since one retrospective study has not been conclusive, we support the idea that prospective trials are necessary. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/30610500; PUBMED: 30610500 |
| DOI: | 10.1007/s10143-018-01074-0 |
| الاتاحة: | https://hal.sorbonne-universite.fr/hal-01983098 https://hal.sorbonne-universite.fr/hal-01983098v1/document https://hal.sorbonne-universite.fr/hal-01983098v1/file/Neurosurgical%20Review%202019%20-%20Propranolol%20in%20cavernomas_sans%20marque.pdf https://doi.org/10.1007/s10143-018-01074-0 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.BD9EB50C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s10143-018-01074-0 |
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