Academic Journal
P52 Immune-mediated diabetes secondary to the use of immune checkpoint inhibitors
| العنوان: | P52 Immune-mediated diabetes secondary to the use of immune checkpoint inhibitors |
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| المؤلفون: | Antonela Mainardi, Melina Saban, Maricel Recalde, Carlos Silva, Mariana Curriá |
| المصدر: | Revista de la Sociedad Argentina de Diabetes, Vol 54, Iss 3Sup, Pp 157-157 (2020) |
| بيانات النشر: | Sello Editorial Lugones |
| سنة النشر: | 2020 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | diabetes inmunomediada, inhibidores de los checkpoint inmune, Nutritional diseases. Deficiency diseases, RC620-627, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| الوصف: | Introduction: The use of immune check point inhibitors (ICIs) modified the focus of cancer therapy. ICIs are monoclonal auto-antibodies directed against inhibitory T cell receptors (immune checkpoints), which act as negative co-regulators to limit immune activation. Adverse events related to the endocrine system (irAE) are observed between 4-30%. Immune-mediated diabetes mellitus (DM) is the least frequent complication (less than 1%) but is potentially fatal. Objectives: To describe the characteristics and frequency of immune-mediated DM in patients with ICIs. Materials and methods: Retrospective, descriptive, observational study. It included patients of both genders older than 18 years in treatment with ICIs from 2018 to date. Hormone profile and fasting plasma glucose were requested in basal conditions and prior to each infusion. Categorical variables are expressed as a percentage and continuous variables, as median and intercuratil range (IQR). |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | Spanish; Castilian |
| تدمد: | 0325-5247 2346-9420 |
| Relation: | https://revistasad.com/index.php/diabetes/article/view/438; https://doaj.org/toc/0325-5247; https://doaj.org/toc/2346-9420; https://doaj.org/article/2417c8a17f9f468f83a97c89cfb642e4 |
| DOI: | 10.47196/diab.v54i3Sup.438 |
| الاتاحة: | https://doi.org/10.47196/diab.v54i3Sup.438 https://doaj.org/article/2417c8a17f9f468f83a97c89cfb642e4 |
| رقم الانضمام: | edsbas.BD7573D |
| قاعدة البيانات: | BASE |
| تدمد: | 03255247 23469420 |
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| DOI: | 10.47196/diab.v54i3Sup.438 |