Academic Journal
Involvement of mechano-sensitive Piezo1 channel in the differentiation of brown adipocytes
| العنوان: | Involvement of mechano-sensitive Piezo1 channel in the differentiation of brown adipocytes |
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| المؤلفون: | Kenmochi, Manato, Kawarasaki, Satoko, Takizawa, Satsuki, Okamura, Kazuhiko, Goto, Tsuyoshi, Uchida, Kunitoshi |
| المساهمون: | Japan Society for the Promotion of Science, Takeda Science Foundation |
| المصدر: | The Journal of Physiological Sciences ; volume 72, issue 1 ; ISSN 1880-6546 1880-6562 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2022 |
| الوصف: | Brown adipocytes expend energy via heat production and are a potential target for the prevention of obesity and related metabolic disorders. Piezo1 is a Ca 2+ -permeable non-selective cation channel activated by mechanical stimuli. Piezo1 is reported to be involved in mechano-sensation in non-sensory tissues. However, the expression and roles of Piezo1 in brown adipocytes have not been well clarified. Here, we generated a brown adipocyte line derived from UCP1-mRFP1 transgenic mice and showed that Piezo1 is expressed in pre-adipocytes. Application of Yoda-1, a Piezo1 agonist, suppressed brown adipocyte differentiation, and this suppression was significantly attenuated by treatment with a Piezo1 antagonist and by Piezo1 knockdown. Furthermore, the suppression of brown adipocyte differentiation by Yoda-1 was abolished by co-treatment with a calcineurin inhibitor. Thus, these results suggest that activation of Piezo1 suppresses brown adipocyte differentiation via the calcineurin pathway. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1186/s12576-022-00837-1 |
| DOI: | 10.1186/s12576-022-00837-1.pdf |
| DOI: | 10.1186/s12576-022-00837-1/fulltext.html |
| الاتاحة: | http://dx.doi.org/10.1186/s12576-022-00837-1 https://link.springer.com/content/pdf/10.1186/s12576-022-00837-1.pdf https://link.springer.com/article/10.1186/s12576-022-00837-1/fulltext.html |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.BD42ABF9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12576-022-00837-1 |
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