Academic Journal
Detection of Small Airway Dysfunction in Asthmatic Patients by Spirometry and Impulse Oscillometry System
| العنوان: | Detection of Small Airway Dysfunction in Asthmatic Patients by Spirometry and Impulse Oscillometry System |
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| المؤلفون: | Pisi, Roberta, Aiello, Marina, Frizzelli, Annalisa, Feci, Davide, Aredano, Ilaria, Manari, Gaia, Calzetta, Luigino, Pelà, Giovanna, Chetta, Alfredo |
| المصدر: | Respiration ; volume 102, issue 7, page 487-494 ; ISSN 0025-7931 1423-0356 |
| بيانات النشر: | S. Karger AG |
| سنة النشر: | 2023 |
| الوصف: | Background: There is no gold standard in diagnosing SAD. Indicators of SAD are considered: (a) a value <65% of predicted values of two of three measures, FEF25-75, FEF50 e FEF75 (FEF+); (b) a value of FEV3/FEV6 < LLN (FEV3/FEV6+); (c) an IOS value of R5-R20 >0.07 kPa·s·L−1 (R5-R20+). Aim and Objectives: The aim of the study was to ascertain, in asthmatic patients, whether spirometry and IOS indicators agree in detecting SAD. We also assessed the relationship between spirometry and IOS indicators and clinical features of asthma. Methods: We prospectively recruited adult asthmatic patients. Anthropometric and clinical characteristics were recorded. All patients performed spirometry and IOS tests. Results: We enrolled 301 asthmatic patients (179 females; mean age 50 ± 16 years) with normal to moderately severe degree of airway obstruction; 91% were non-smokers, 74% were atopic, 28% had an exacerbation in the previous year, and 18% had a poor asthma control by ACT. SAD was diagnosed in 62% of patients through FEF+, in 40% through FEV3/FEV6+ and in 41% through R5-R20+. κ values were 0.49 between FEF+ and FEV3/FEV6+, 0.20 between FEF+ and R5-R20+, 0.07 between FEV3/FEV6+ and R5-R20+. R5-R20+ but not FEF+ and FEV3/FEV6+ was significantly associated with ACT score (p < 0.05). Conclusions: Our study shows that in mild to moderately severe asthmatic patients, spirometry and IOS indicators are complementary in diagnosing SAD. Additionally, IOS indicator, but not spirometry ones, was related to asthma control. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1159/000531205 |
| الاتاحة: | http://dx.doi.org/10.1159/000531205 https://karger.com/res/article-pdf/102/7/487/4022773/000531205.pdf |
| Rights: | https://creativecommons.org/licenses/by-nc/4.0/ ; https://creativecommons.org/licenses/by-nc/4.0/ |
| رقم الانضمام: | edsbas.BD30D58A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1159/000531205 |
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