Academic Journal
Defining the optimum strategy for identifying adults and children with coeliac disease: systematic review and economic modelling
| العنوان: | Defining the optimum strategy for identifying adults and children with coeliac disease: systematic review and economic modelling |
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| المؤلفون: | Martha MC Elwenspoek, Howard Thom, Athena L Sheppard, Edna Keeney, Rachel O’Donnell, Joni Jackson, Cristina Roadevin, Sarah Dawson, Deborah Lane, Jo Stubbs, Hazel Everitt, Jessica C Watson, Alastair D Hay, Peter Gillett, Gerry Robins, Hayley E Jones, Sue Mallett, Penny F Whiting |
| المصدر: | Health Technology Assessment, Vol 26, Iss 44 (2022) |
| بيانات النشر: | NIHR Journals Library |
| سنة النشر: | 2022 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | coeliac disease, primary care, risk factors, diagnostic tests, economic models, immunoglobulin a endomysial antibodies, immunoglobulin a anti tissue transglutaminase, biopsy, survey, cost-effectiveness, gluten-free diet, children, Medical technology, R855-855.5 |
| الوصف: | Background: Coeliac disease is an autoimmune disorder triggered by ingesting gluten. It affects approximately 1% of the UK population, but only one in three people is thought to have a diagnosis. Untreated coeliac disease may lead to malnutrition, anaemia, osteoporosis and lymphoma. Objectives: The objectives were to define at-risk groups and determine the cost-effectiveness of active case-finding strategies in primary care. Design: (1) Systematic review of the accuracy of potential diagnostic indicators for coeliac disease. (2) Routine data analysis to develop prediction models for identification of people who may benefit from testing for coeliac disease. (3) Systematic review of the accuracy of diagnostic tests for coeliac disease. (4) Systematic review of the accuracy of genetic tests for coeliac disease (literature search conducted in April 2021). (5) Online survey to identify diagnostic thresholds for testing, starting treatment and referral for biopsy. (6) Economic modelling to identify the cost-effectiveness of different active case-finding strategies, informed by the findings from previous objectives. Data sources: For the first systematic review, the following databases were searched from 1997 to April 2021: MEDLINE® (National Library of Medicine, Bethesda, MD, USA), Embase® (Elsevier, Amsterdam, the Netherlands), Cochrane Library, Web of Science™ (Clarivate™, Philadelphia, PA, USA), the World Health Organization International Clinical Trials Registry Platform (WHO ICTRP) and the National Institutes of Health Clinical Trials database. For the second systematic review, the following databases were searched from January 1990 to August 2020: MEDLINE, Embase, Cochrane Library, Web of Science, Kleijnen Systematic Reviews (KSR) Evidence, WHO ICTRP and the National Institutes of Health Clinical Trials database. For prediction model development, Clinical Practice Research Datalink GOLD, Clinical Practice Research Datalink Aurum and a subcohort of the Avon Longitudinal Study of Parents and Children were used; ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1366-5278 2046-4924 |
| Relation: | https://doi.org/10.3310/ZUCE8371; https://doaj.org/toc/1366-5278; https://doaj.org/toc/2046-4924; https://doaj.org/article/21a6f080ef7348e891556a17d90951b8 |
| DOI: | 10.3310/ZUCE8371 |
| الاتاحة: | https://doi.org/10.3310/ZUCE8371 https://doaj.org/article/21a6f080ef7348e891556a17d90951b8 |
| رقم الانضمام: | edsbas.BD2F9E4E |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 13665278 20464924 |
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| DOI: | 10.3310/ZUCE8371 |