التفاصيل البيبلوغرافية
| العنوان: |
Ultrasound Microbubbles Mediated Sonosensitizer and Antibody Co-delivery for Highly Efficient Synergistic Therapy on HER2-Positive Gastric Cancer |
| المؤلفون: |
Lihong Sun (680783), Jinxia Zhang (496327), Menghong Xu (11036626), Lulu Zhang (104611), Qingshuang Tang (11036623), Jing Chen (4762), Ming Gong (383231), Suhui Sun (10674501), Huiyu Ge (11880956), Shumin Wang (402967), Xiaolong Liang (1651279), Ligang Cui (5328320) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biophysics, Medicine, Pharmacology, Biotechnology, Cancer, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, positive gastric cancer, good biological safety, fluorescence bimodal imaging, 1 times ), limited therapeutic efficiency, targeted microbubble destruction, n87 cell models, achieve targeting combination, tumor inhibition rate, tp mbs ), synergistic therapeutic effect, poor delivery efficiency, serious side effects, tp mbs combined, tp mbs, targeting effects, side effects, tp nps, killing effect, retention effects, tumor tissue, tumor growth |
| الوصف: |
Trastuzumab combined with chemotherapy is the first-line treatment for advanced HER2-positive gastric cancer, but it still suffers from limited therapeutic efficiency and serious side effects, which are usually due to the poor delivery efficiency and the drug resistance of tumor cells to the chemotherapeutic drugs. Herein, a type of ultrasound microbubble for simultaneous delivery of sonosensitizers and therapeutic antibodies to achieve targeting combination of sonodynamic therapy and antibody therapy of HER2-positive gastric cancer was constructed from pyropheophorbide-lipid followed by trastuzumab conjugation (TP MBs). In vitro and in vivo studies showed that TP MBs had good biological safety, and their in vivo delivery can be monitored by ultrasound/fluorescence bimodal imaging. With ultrasound (US) located at the tumor area, TP MBs can be converted into nanoparticles (TP NPs) in situ by US-targeted microbubble destruction; plus the enhanced permeability and retention effects and the targeting effects of trastuzumab, the enrichment of sonosensitizers and antibodies in the tumor tissue can be greatly enhanced (∼2.1 times). When combined with ultrasound, TP MBs can not only increase the uptake of sonosensitizers in HER2-positive gastric cancer NCI-N87 cells but also efficiently generate singlet oxygen to greatly increase the killing effect on cells, obviously inhibiting the tumor growth in HER2-positive gastric cancer NCI-N87 cell models with a tumor inhibition rate up to 79.3%. Overall, TP MBs combined with US provided an efficient way for co-delivery of sonosensitizers and antibodies, greatly enhancing the synergistic therapeutic effect on HER2-positive gastric cancer while effectively reducing the side effects. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/journal_contribution/Ultrasound_Microbubbles_Mediated_Sonosensitizer_and_Antibody_Co-delivery_for_Highly_Efficient_Synergistic_Therapy_on_HER2-Positive_Gastric_Cancer/17696534 |
| DOI: |
10.1021/acsami.1c21924.s001 |
| الاتاحة: |
https://doi.org/10.1021/acsami.1c21924.s001 |
| Rights: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.BD1E3749 |
| قاعدة البيانات: |
BASE |