Academic Journal
THE SUBDIVISION OF β‐ADRENOCEPTORS IN THE CARDIOVASCULAR SYSTEM OF THE RAT
| العنوان: | THE SUBDIVISION OF β‐ADRENOCEPTORS IN THE CARDIOVASCULAR SYSTEM OF THE RAT |
|---|---|
| المؤلفون: | IMMS, F.J., NEAME, R.L.B., POWIS, D.A. |
| المصدر: | British Journal of Pharmacology ; volume 67, issue 3, page 367-370 ; ISSN 0007-1188 1476-5381 |
| بيانات النشر: | Wiley |
| سنة النشر: | 1979 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | The antagonism by the β‐adrenoceptor blocking drugs, propranolol (non‐selective) and practolol (β‐selective), of the cardiovascular actions of isoprenaline has been investigated in the rat. All doses of practolol (0.1, 1 and 3 mg/kg) blocked the cardio‐accelerator action of isoprenaline but only the largest dose blocked the vasodilator effect. All doses of propranolol (0.01, 0.03 and 0.1 mg/kg) blocked the vasodilator effect of isoprenaline but only the largest dose diminished the tachycardia. It is concluded that in the rat, as in other species, β‐adrenoceptors may be subdivided into β 1 (cardiac) and β 2 (peripheral vascular) types. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/j.1476-5381.1979.tb08689.x |
| الاتاحة: | http://dx.doi.org/10.1111/j.1476-5381.1979.tb08689.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1476-5381.1979.tb08689.x https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1476-5381.1979.tb08689.x |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.BD1C3E68 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/j.1476-5381.1979.tb08689.x |
|---|