Academic Journal
Characterization of sinoatrial automaticity in Microcebus murinus to study the effect of aging on cardiac activity and the correlation with longevity
| العنوان: | Characterization of sinoatrial automaticity in Microcebus murinus to study the effect of aging on cardiac activity and the correlation with longevity |
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| المؤلفون: | Difrancesco, Mattia, Marrot, Manon, Torre, Eleonora, Mesirca, Pietro, Davaze, Romain, Lautier, Corinne, Fontes, Pascaline, Cuoq, Joël, Fernandez, Anne, Lamb, Ned, Pifferi, Fabien, Mestre-Francés, Nadine, Mangoni, Matteo E., Torrente, Angelo |
| المساهمون: | Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), LabEx Ion Channels Science and Therapeutics France, IRCCS Ospedale Policlinico San Martino Genoa, Italy, Institut de génétique humaine (IGH), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Mécanismes moléculaires dans les démences neurodégénératives (MMDN), École Pratique des Hautes Études (EPHE), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Mécanismes Adaptatifs et Evolution (MECADEV), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), Université Paris Sciences et Lettres (PSL), ANR-11-LABX-0015,ICST,Canaux ioniques d'intérêt thérapeutique(2011), ANR-10-BLAN-1128,Beat-Genesis,Génétique et Physiologie de la génération de l'automatisme cardiaque(2010), ANR-15-CE14-0004,BradyCardia_Care,Physiopathologie de l'activité pace-maker cardiaque: nouvelles pistes thérapeutiques pour la bradycardie(2015) |
| المصدر: | ISSN: 2045-2322. |
| بيانات النشر: | HAL CCSD Nature Publishing Group |
| سنة النشر: | 2023 |
| المجموعة: | Muséum National d'Histoire Naturelle (MNHM): HAL |
| مصطلحات موضوعية: | [SDV.BA]Life Sciences [q-bio]/Animal biology, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system |
| الوصف: | International audience ; Microcebus murinus, or gray mouse lemur (GML), is one of the smallest primates known, with a size in between mice and rats. The small size, genetic proximity to humans and prolonged senescence, make this lemur an emerging model for neurodegenerative diseases. For the same reasons, it could help understand how aging affects cardiac activity. Here, we provide the first characterization of sinoatrial (SAN) pacemaker activity and of the effect of aging on GML heart rate (HR). According to GML size, its heartbeat and intrinsic pacemaker frequencies lie in between those of mice and rats. To sustain this fast automaticity the GML SAN expresses funny and Ca2+ currents (If, ICa,L and ICa,T) at densities similar to that of small rodents. SAN automaticity was also responsive to β-adrenergic and cholinergic pharmacological stimulation, showing a consequent shift in the localization of the origin of pacemaker activity. We found that aging causes decrease of basal HR and atrial remodeling in GML. We also estimated that, over 12 years of a lifetime, GML generates about 3 billion heartbeats, thus, as many as humans and three times more than rodents of equivalent size. In addition, we estimated that the high number of heartbeats per lifetime is a characteristic that distinguishes primates from rodents or other eutherian mammals, independently from body size. Thus, cardiac endurance could contribute to the exceptional longevity of GML and other primates, suggesting that GML's heart sustains a workload comparable to that of humans in a lifetime. In conclusion, despite the fast HR, GML replicates some of the cardiac deficiencies reported in old people, providing a suitable model to study heart rhythm impairment in aging. Moreover, we estimated that, along with humans and other primates, GML presents a remarkable cardiac longevity, enabling longer life span than other mammals of equivalent size. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/36810863; hal-04010411; https://hal.science/hal-04010411; https://hal.science/hal-04010411/document; https://hal.science/hal-04010411/file/41598_2023_Article_29723.pdf; PUBMED: 36810863; PUBMEDCENTRAL: PMC9944915 |
| DOI: | 10.1038/s41598-023-29723-5 |
| الاتاحة: | https://hal.science/hal-04010411 https://hal.science/hal-04010411/document https://hal.science/hal-04010411/file/41598_2023_Article_29723.pdf https://doi.org/10.1038/s41598-023-29723-5 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.BD0483DC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-023-29723-5 |
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