Academic Journal
Low prevalence of colorectal neoplasia in microscopic colitis : A large prospective multi-center study
| العنوان: | Low prevalence of colorectal neoplasia in microscopic colitis : A large prospective multi-center study |
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| المؤلفون: | Borsotti E., Barberio B., D'Inca R., Bonitta G., Cavallaro F., Spina L., Pastorelli L., Rondonotti E., Samperi L., Dinelli M., Vecchi M., Tontini G. E. |
| المساهمون: | E. Borsotti, B. Barberio, R. D'Inca, G. Bonitta, F. Cavallaro, L. Spina, L. Pastorelli, E. Rondonotti, L. Samperi, M. Dinelli, M. Vecchi, G.E. Tontini |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2021 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | Advanced endoscopic imaging, Chronic non-bloody diarrhea, Collagenous coliti, Colorectal adenoma, Colorectal cancer, Lymphocytic coliti, Microscopic colitis, Settore MED/12 - Gastroenterologia |
| الوصف: | Background and Aims: Microscopic colitis (MC) is the most frequent condition in subjects undergoing ileocolonoscopy for chronic non-bloody diarrhea (CNBD) in Western countries. Emerging evidence has shown a negative association between MC and colorectal cancer. Within this prospective multi-center study we have evaluated the risk of colorectal neoplasia in MC and non-MC patients with CNBD receiving ileocolonoscopy with high-definition plus virtual chromoendoscopic imaging and histopathological assessment. Methods: Patients with CNBD of unknown origin were prospectively enrolled in 5 referral centers in Northern Italy for ileocolonoscopy with high-definition and digital/optical chromoendoscopy plus multiple biopsies in each segment. The prevalence of colorectal neoplasia (cancer, adenoma, serrated lesion) in MC was compared to that observed in a control group including CNBD patients negative for MC, inflammatory bowel disease or eosinophilic colitis. Results: From 2014 and 2017, 546 consecutive CNBD patients were recruited. Among the 492 patients (mean age 53±18 years) fulfilling the inclusion criteria against the exclusion critieria, MC was the predominant diagnosis at histopathological assessment (8.7%: N=43, 28 CC, 15 LC). The regression model adjusted for age and gender showed a significant negative association between the diagnosis of CM and colorectal neoplasia (OR=0.39; 95% CI 0.22−0.67, p <0.001) with a 60% decreased risk of adenomatous and neoplastic serrated polyps as compared to the control group (n=412). Conclusion: This multi-center study confirms MC as a low-risk condition for colorectal neoplasia. No surveillance colonoscopy program is to be performed for MC diagnosis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/33129712; info:eu-repo/semantics/altIdentifier/wos/WOS:000670070300010; volume:53; issue:7; firstpage:846; lastpage:851; numberofpages:6; journal:DIGESTIVE AND LIVER DISEASE; http://hdl.handle.net/2434/863622; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85094561961 |
| DOI: | 10.1016/j.dld.2020.09.024 |
| الاتاحة: | http://hdl.handle.net/2434/863622 https://doi.org/10.1016/j.dld.2020.09.024 |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.BCA10243 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.dld.2020.09.024 |
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