Academic Journal
Changes in histone lysine acetylation, but not DNA methylation during facultative hibernation in Syrian hamster liver
| العنوان: | Changes in histone lysine acetylation, but not DNA methylation during facultative hibernation in Syrian hamster liver |
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| المؤلفون: | Oosterhof, Marloes, Coussement, Louis, van Pijkeren, Alienke, Kwiatkowski, Marcel, Zwinderman, Martijn R. H., Dekker, Frank J., De Meyer, Tim, Reitsema, Vera A., Bischoff, Rainer, Guryev, Victor, Bouma, Hjalmar R., Henning, Rob H., Rots, Marianne G. |
| المصدر: | EPIGENETICS COMMUNICATIONS ; ISSN: 2730-7034 |
| سنة النشر: | 2024 |
| المجموعة: | Ghent University Academic Bibliography |
| مصطلحات موضوعية: | Biology and Life Sciences, HDAC, HAT, RNA sequencing, Epigenetics, Histone acetylation, WGBS |
| الوصف: | Background Hibernation (torpor) is a strategy to survive extreme environmental conditions, associated with a significant decrease in metabolism and body temperature. The inducibility by the environment of torpor for facultative hibernators designates epigenetic mechanisms as likely candidates for regulation. Therefore, we set out to unravel epigenetics in the liver of a facultative hibernator, Syrian hamster (Mesocricetus auratus), sampled at different phases during hibernation, by assessing the expression of epigenetic writer and eraser enzymes, histone acetylation dynamics, and DNA methylation levels. Results Expression of epigenetic writers/erasers confirmed previously reported results obtained in obligatory hibernators, but might point to a mechanism specific for facultative hibernators, e.g., differential expression of histone acetyltransferases (HATs; KAT6A, KAT6B, KAT7, and KAT13D/CLOCK). These findings were in accordance with observed changes in histone H3 and H4 acetylation changes. Overall histone deacetylase (HDAC) activity was highest in torpor. No differences were detected in DNA methylation throughout all phases. Conclusion Our study thus points to histone acetylation as an important player in facultative hamster hibernation, which may underlie the orchestration of gene expression changes throughout hibernation. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://biblio.ugent.be/publication/01J03AQ4W54JP6QJ5DDVWEND11; http://hdl.handle.net/1854/LU-01J03AQ4W54JP6QJ5DDVWEND11; http://doi.org/10.1186/s43682-023-00024-2; https://biblio.ugent.be/publication/01J03AQ4W54JP6QJ5DDVWEND11/file/01J03ATC83B7ZDB67V7CP1S7P7 |
| DOI: | 10.1186/s43682-023-00024-2 |
| الاتاحة: | https://biblio.ugent.be/publication/01J03AQ4W54JP6QJ5DDVWEND11 http://hdl.handle.net/1854/LU-01J03AQ4W54JP6QJ5DDVWEND11 https://doi.org/10.1186/s43682-023-00024-2 https://biblio.ugent.be/publication/01J03AQ4W54JP6QJ5DDVWEND11/file/01J03ATC83B7ZDB67V7CP1S7P7 |
| Rights: | Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.BC4E56EE |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s43682-023-00024-2 |
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