Academic Journal
Early detection of cardiovascular changes after radiotherapy for breast cancer : protocol for a european multicenter prospective cohort study (MEDIRAD EARLY HEART Study)
| العنوان: | Early detection of cardiovascular changes after radiotherapy for breast cancer : protocol for a european multicenter prospective cohort study (MEDIRAD EARLY HEART Study) |
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| المؤلفون: | Walker, Valentin, Crijns, Anne, Langendijk, Johannes, Spoor, Daan, Vliegenthart, Rozemarijn, Combs, Stephanie E., Mayinger, Michael, Eraso, Arantxa, Guedea, Ferran, Fiuza, Manuela, Santos, Susana Constantino Rosa, Tamarat, Radia, Laurier, Dominique, Ferrières, Jean, Mousseaux, Elie, Cardis, Elisabeth, Jacob, Sophie |
| بيانات النشر: | JMIR Publications |
| سنة النشر: | 2019 |
| المجموعة: | Universidade de Lisboa: repositório.UL |
| مصطلحات موضوعية: | Biomarkers, Breast cancer, Cardiotoxicity, Cardiac diagnostic imaging, Radiotherapy, Radiation dosimetry |
| الوصف: | © Valentin Walker, Anne Crijns, Johannes Langendijk, Daan Spoor, Rozemarijn Vliegenthart, Stephanie E Combs, Michael Mayinger, Arantxa Eraso, Ferran Guedea, Manuela Fiuza, Susana Constantino, Radia Tamarat, Dominique Laurier, Jean Ferrières, Elie Mousseaux, Elisabeth Cardis, Sophie Jacob. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 01.10.2018. This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Research Protocols, is properly cited. The complete bibliographic information, a link to the original publication on http://www.researchprotocols.org, as well as this copyright and license information must be included. ; Background: Breast cancer is the most common cancer among women, and radiotherapy plays a major role in its treatment. However, breast cancer radiotherapy can lead to incidental irradiation of the heart, resulting in an increased risk for a variety of heart diseases arising many years after radiotherapy. Therefore, identifying breast cancer patients at the highest risk for radiation-induced cardiac complications is crucial for developing strategies for primary and secondary prevention, which may contribute to healthy aging. There is still a need for precise knowledge on the relationship between radiation dose to specific cardiac structures and early subclinical cardiac changes and their occurrence over time that could finally lead to cardiac complications. Objective: The MEDIRAD EARLY HEART study aims to identify and validate new cardiac imaging and circulating biomarkers of radiation-induced cardiovascular changes arising within first 2 years of breast cancer radiotherapy and to develop risk models integrating these biomarkers combined with precise dose metrics of cardiac structures based on three-dimensional dosimetry. Methods: The EARLY ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1929-0748 |
| Relation: | https://www.researchprotocols.org/; JMIR Res Protoc 2018;7(10):e178; http://hdl.handle.net/10451/38736 |
| DOI: | 10.2196/resprot.9906 |
| الاتاحة: | http://hdl.handle.net/10451/38736 https://doi.org/10.2196/resprot.9906 |
| Rights: | openAccess ; http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.BC3436AC |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19290748 |
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| DOI: | 10.2196/resprot.9906 |