Academic Journal
Pravastatin for early‐onset pre‐eclampsia: a randomised, blinded, placebo‐controlled trial
| العنوان: | Pravastatin for early‐onset pre‐eclampsia: a randomised, blinded, placebo‐controlled trial |
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| المؤلفون: | Ahmed, A, Williams, Dj, Cheed, V, Middleton, Lj, Ahmad, S, Wang, K, Vince, At, Hewett, P, Spencer, K, Khan, Ks, Daniels, Jp, Barber, Katherine, Kilby, Mark, Knox, Ellen, Sellman, Tara, Trinham, Paula, Tuffnell, Derek, Jones, Vicky, Syson, Jennifer, Shah, Neil, Deeks, Laurie, Carter, Wendy, Dorman, Ed, Thomas, Susannah, Harrington, Deborah, Higgins, Nicola, Wilmott‐powell, Mirriam, Simpson, Nigel, Dolby, Vivian, Bricker, Leanne, Walkinshaw, Steve, Houghton, Gillian, Longworth, Heather, Williamson, Catherine, Dhanjal, Mandish, Noori, Muna, Machirori, Mavis, Howard, Richard, Murray, Rebecca, Weist, Sarah, Denison, Fiona, Crawford, Isobel, Robson, Stephen, Allan, Carly, Myers, Jenny, Bernatavicius, Giovanna, Moorhead, Lynsey, Chappell, Lucy, Nelson‐piercy, Catherine, Williams, David, Daley, Rebecca, Rosas, Miguel, Greer, Ian, Vitek, Libor, Shennan, Andy, Marlow, Neil, Barnard, Ann Marie, Thornton, Jim, Rennie, Janet, Peacock, Janet, Gao Smith, Fang, Hyde, Carolyn, Cudmore, Melissa, Furmston, Alex, Fulcher, Leanne, Homer, Leanne, Howman, Andrew, Hilken, Nicholas, Brown, Stephen |
| المصدر: | Ahmed , A , Williams , D , Cheed , V , Middleton , L , Ahmad , S , Wang , K , Vince , A , Hewett , P , Spencer , K , Khan , K , Daniels , J , Barber , K , Kilby , M , Knox , E , Sellman , T , Trinham , P , Tuffnell , D , Jones , V , Syson , J , Shah , N , Deeks , L , Carter , W , Dorman , E , Thomas , S , Harrington , D .... |
| سنة النشر: | 2020 |
| المجموعة: | King's College, London: Research Portal |
| مصطلحات موضوعية: | Anti-angiogenic factor, double-blind, perinatal mortality, placebo-controlled, pravastatin, pre-eclampsia, randomised trial, statin |
| الوصف: | Objective: Women with pre-eclampsia have elevated circulating levels of soluble fms-like tyrosine kinase-1 (sFlt-1). Statins can reduce sFlt-1 from cultured cells and improve pregnancy outcome in animals with a pre-eclampsia-like syndrome. We investigated the effect of pravastatin on plasma sFlt-1 levels during pre-eclampsia. Design: Blinded (clinician and participant), proof of principle, placebo-controlled trial. Setting: Fifteen UK maternity units. Population: We used a minimisation algorithm to assign 62 women with early-onset pre-eclampsia (24 +0 –31 +6 weeks of gestation) to receive pravastatin 40 mg daily (n = 30) or matched placebo (n = 32), from randomisation to childbirth. Primary outcome: Difference in mean plasma sFlt-1 levels over the first 3 days following randomisation. Results: The difference in the mean maternal plasma sFlt-1 levels over the first 3 days after randomisation between the pravastatin (n = 27) and placebo (n = 29) groups was 292 pg/ml (95% CI −1175 to 592; P = 0.5), and over days 1–14 was 48 pg/ml (95% CI −1009 to 913; P = 0.9). Women who received pravastatin had a similar length of pregnancy following randomisation compared with those who received placebo (hazard ratio 0.84; 95% CI 0.50–1.40; P = 0.6). The median time from randomisation to childbirth was 9 days (interquartile range [IQR] 5–14 days) for the pravastatin group and 7 days (IQR 4–11 days) for the placebo group. There were three perinatal deaths in the placebo-treated group and no deaths or serious adverse events attributable to pravastatin. Conclusions: We found no evidence that pravastatin lowered maternal plasma sFlt-1 levels once early-onset pre-eclampsia had developed. Pravastatin appears to have no adverse perinatal effects. Tweetable abstract: Pravastatin does not improve maternal plasma sFlt-1 or placental growth factor levels following a diagnosis of early preterm pre-eclampsia #clinicaltrial finds. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/1471-0528.16013 |
| الاتاحة: | https://kclpure.kcl.ac.uk/portal/en/publications/855d5b44-a53c-4b47-87a1-b0dce894f38e https://doi.org/10.1111/1471-0528.16013 http://www.scopus.com/inward/record.url?scp=85077081210&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.BC14299B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/1471-0528.16013 |
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