| الوصف: |
Monkgomotsi J Maseng, 1, 2 Leabaneng Tawe, 1– 3 Prisca K Thami, 2, 4 Kaelo K Seatla, 1, 2 Sikhulile Moyo, 2, 5 Axel Martinelli, 6 Ishmael Kasvosve, 1 Vladimir Novitsky, 2, 5 Max Essex, 2, 5 Gianluca Russo, 7 Simani Gaseitsiwe, 2, 5 Giacomo M Paganotti 3, 8, 9 1School of Allied Health Professions, Faculty of Health Sciences, University of Botswana, Gaborone, Botswana; 2Botswana-Harvard AIDS Institute Partnership, Gaborone, Botswana; 3Botswana-University of Pennsylvania Partnership, Gaborone, Botswana; 4Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; 5Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA; 6BigOmics Analytics, Bellinzona, Switzerland; 7Department of Public Health and Infectious Disease, Faculty of Medicine, Sapienza University of Rome, Rome, Italy; 8Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; 9Department of Biomedical Sciences, Faculty of Medicine, University of Botswana, Gaborone, BotswanaCorrespondence: Giacomo M PaganottiBotswana-University of Pennsylvania Partnership, PO Box AC 147 ACH, Gaborone, BotswanaTel +267 76416198Email paganottig@bup.org.bwPurpose: CYP2B6 liver enzyme metabolizes the two non-nucleoside reverse transcriptase inhibitors Efavirenz (EFV) and Nevirapine (NVP) used in the antiretroviral therapy (ART) regimens for HIV-infected individuals. Polymorphisms of the CYP2B6 gene influence drug levels in plasma and possibly virological outcomes. The aim of this study was to explore the potential impact of CYP2B6 genotype and haplotype variation on the risk of developing EFV/NVP drug resistance mutations (DRMs) in HIV-1 patients receiving EFV-/NVP-containing regimens in Botswana.Patients and Methods: Participants were a sub-sample of a larger study (Tshepo study) conducted in Gaborone, Botswana, among HIV-infected individuals taking EFV/NVP containing ART. Study samples were retrieved and ... |