Academic Journal
Retinoic acid receptor activation reprograms senescence response and enhances anti-tumor activity of natural killer cells
| العنوان: | Retinoic acid receptor activation reprograms senescence response and enhances anti-tumor activity of natural killer cells |
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| المؤلفون: | Colucci, Manuel, Zumerle, Sara, Bressan, Silvia, Gianfanti, Federico, Troiani, Martina, Valdata, Aurora, D’Ambrosio, Mariantonietta, Pasquini, Emiliano, Varesi, Angelica, Cogo, Francesca, Mosole, Simone, Dongilli, Cristina, Desbats, Maria Andrea, Contu, Liliana, Revankdar, Ajinkya, Chen, Jingjing, Kalathur, Madhuri, Perciato, Maria Luna, Basilotta, Rossella, Endre, Laczko, Schauer, Stefan, Othman, Alaa, Guccini, Ilaria, Saponaro, Miriam, Maraccani, Luisa, Bancaro, Nicolò, Lai, Ping, Liu, Lei, Pernigoni, Nicolò, Mele, Federico |
| المصدر: | Colucci, Manuel; Zumerle, Sara; Bressan, Silvia; Gianfanti, Federico; Troiani, Martina; Valdata, Aurora; D’Ambrosio, Mariantonietta; Pasquini, Emiliano; Varesi, Angelica; Cogo, Francesca; Mosole, Simone; Dongilli, Cristina; Desbats, Maria Andrea; Contu, Liliana; Revankdar, Ajinkya; Chen, Jingjing; Kalathur, Madhuri; Perciato, Maria Luna; Basilotta, Rossella; Endre, Laczko; Schauer, Stefan; Othman, Alaa; Guccini, Ilaria; Saponaro, Miriam; Maraccani, Luisa; Bancaro, Nicolò; Lai, Ping; Liu, Lei; Pernigoni, Nicolò; Mele, Federico; et al (2024). Retinoic acid receptor activation reprograms senescence response and enhances anti-tumor activity of natural killer cells. Cancer Cell, 42(4):646-661.e9. |
| بيانات النشر: | Cell Press (Elsevier) |
| سنة النشر: | 2024 |
| المجموعة: | University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
| مصطلحات موضوعية: | Functional Genomics Center Zurich, Institute of Experimental Immunology, 610 Medicine & health, 570 Life sciences, biology |
| الوصف: | Cellular senescence can exert dual effects in tumors, either suppressing or promoting tumor progression. The senescence-associated secretory phenotype (SASP), released by senescent cells, plays a crucial role in this dichotomy. Consequently, the clinical challenge lies in developing therapies that safely enhance senescence in cancer, favoring tumor-suppressive SASP factors over tumor-promoting ones. Here, we identify the retinoic-acid-receptor (RAR) agonist adapalene as an effective pro-senescence compound in prostate cancer (PCa). Reactivation of RARs triggers a robust senescence response and a tumor-suppressive SASP. In preclinical mouse models of PCa, the combination of adapalene and docetaxel promotes a tumor-suppressive SASP that enhances natural killer (NK) cell-mediated tumor clearance more effectively than either agent alone. This approach increases the efficacy of the allogenic infusion of human NK cells in mice injected with human PCa cells, suggesting an alternative therapeutic strategy to stimulate the anti-tumor immune response in "immunologically cold" tumors. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1535-6108 |
| Relation: | https://www.zora.uzh.ch/id/eprint/265901/1/ZORA_REF.pdf; info:pmid/38428412; urn:issn:1535-6108 |
| DOI: | 10.1016/j.ccell.2024.02.004 |
| الاتاحة: | https://www.zora.uzh.ch/id/eprint/265901/ https://www.zora.uzh.ch/id/eprint/265901/1/ZORA_REF.pdf https://doi.org/10.1016/j.ccell.2024.02.004 |
| Rights: | info:eu-repo/semantics/openAccess ; Creative Commons: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) ; http://creativecommons.org/licenses/by-nc/4.0/ |
| رقم الانضمام: | edsbas.BC05C831 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 15356108 |
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| DOI: | 10.1016/j.ccell.2024.02.004 |