Academic Journal
Health-Related Quality of Life in Patients With ANCA-Associated Vasculitis and Sinonasal Involvement: A Single-Center Cross-Sectional Study
| العنوان: | Health-Related Quality of Life in Patients With ANCA-Associated Vasculitis and Sinonasal Involvement: A Single-Center Cross-Sectional Study |
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| المؤلفون: | Cazzador, Diego, Padoan, Roberto, Colangeli, Roberta, Pendolino, Alfonso Luca, Felicetti, Mara, Zanoletti, Elisabetta, Emanuelli, Enzo, Martini, Alessandro, Doria, Andrea, Nicolai, Piero, Schiavon, Franco |
| المساهمون: | Cazzador, Diego, Padoan, Roberto, Colangeli, Roberta, Pendolino, Alfonso Luca, Felicetti, Mara, Zanoletti, Elisabetta, Emanuelli, Enzo, Martini, Alessandro, Doria, Andrea, Nicolai, Piero, Schiavon, Franco |
| سنة النشر: | 2020 |
| المجموعة: | Padua Research Archive (IRIS - Università degli Studi di Padova) |
| مصطلحات موضوعية: | ANCA-associated vasculiti, Granulomatosis with polyangiiti, Microscopic polyangiiti, Quality of life, SNOT-22 |
| الوصف: | Background/Objective: The aim of this study was to assess the impact of sinonasal morbidity on quality of life (QoL) in antineutrophil cytoplasmic antibody–associated vasculitis (AAV). Methods: This cross-sectional case-control study enrolled 71 patients—44 AAV cases with (ear, nose, and throat [ENT]–AAV) or without ENT involvement (non–ENT-AAV) undergoing multidisciplinary evaluations and 27 chronic rhinosinusitis (CRS) cases. Three validated QoL questionnaires (Sino-Nasal Outcomes Test-22 [SNOT-22], Nasal Obstruction Symptom Evaluation [NOSE], and Short-Form 36) were administered, and the 3 groups were compared. Results: The ENT-AAV patients were significantly younger (p = 0.01), with less antineutrophil cytoplasmic antibody positivity frequency (p = 0.035) and lower renal involvement (p = 0.003) than the non–ENT-AAV patients. The SNOT-22 questionnaire demonstrated significantly greater sinonasal morbidity in ENT-AAV patients compared with CRS patients (p < 0.001). The NOSE score of ENT-AAV patients was comparable to those of CRS patients, but higher than that of non–ENT-AAV patients (p < 0.001). The SNOT-22 and NOSE scores positively correlated with disease activity (p = 0.037; p = 0.004, respectively). Short-Form 36 domain-by-domain analysis revealed a significantly poorer QoL in ENT-AAV patients, especially with physical functioning being progressively impaired in CRS, non–ENTAAV, and ENT-AAV patients (p < 0.001). No significant differences in QoL came to light when AAV patients were stratified according to current systemic o local treatments. Conclusions: The QoL in AAV patients is significantly reduced, especially in the presence of ENT involvement. The AAV-related nasal morbidity is consistent and comparable to that reported by CRS patients. It significantly affects patients' QoL and in particular social functioning, leading to limitation in daily/work activities. Organ-focused questionnaires and multidisciplinary management are warranted to pursue a treat-to-target approach in these patients. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/33136696; info:eu-repo/semantics/altIdentifier/wos/WOS:000733569200027; volume:Publish Ahead of Print; journal:JCR-JOURNAL OF CLINICAL RHEUMATOLOGY; http://hdl.handle.net/11577/3383941; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85122308248 |
| DOI: | 10.1097/RHU.0000000000001630 |
| الاتاحة: | http://hdl.handle.net/11577/3383941 https://doi.org/10.1097/RHU.0000000000001630 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.BBF8E123 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1097/RHU.0000000000001630 |
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