التفاصيل البيبلوغرافية
| العنوان: |
Establishment of K-18 human ACE2 transgenic mouse SARS-CoV-2 infection model. |
| المؤلفون: |
Conrad E. Z. Chan (11014434), Shirley G. K. Seah (11014437), De Hoe Chye (11014440), Shane Massey (224366), Maricela Torres (11014443), Angeline P. C. Lim (11014446), Steven K. K. Wong (11014449), Jacklyn J. Y. Neo (11014452), Pui San Wong (11014455), Jie Hui Lim (11014458), Gary S. L. Loh (11014461), Dongling Wang (258597), Jerome D. Boyd-Kirkup (11014464), Siyu Guan (11014467), Dipti Thakkar (11014470), Guo Hui Teo (1521718), Kiren Purushotorman (11014473), Paul E. Hutchinson (6458183), Barnaby E. Young (10869381), Jenny G. Low (10499731), Paul A. MacAry (10534724), Hannes Hentze (6680750), Venkateshan S. Prativadibhayankara (11014476), Kantharaj Ethirajulu (2100358), Jason E. Comer (7908407), Chien-Te K. Tseng (492742), Alan D. T. Barrett (8980565), Piers J. Ingram (11014479), Trevor Brasel (502095), Brendon John Hanson (11014482) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biochemistry, Microbiology, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Ecology, Immunology, Cancer, Infectious Diseases, Virology, convalescent COVID -19 patient, anti-SARS-CoV -2 activities, SARS-CoV -2-infected hamsters, IFN, K 18-human ACE 2, attenuated pro-inflammatory responses, SARS-CoV -2 Spike protein, efficacy, Fc-null LALA variant, COVID -19. Importantly, Fc-mediated effector functions, SARS-CoV -2 neutralizing antibody, SC 31 treatment, SARS-CoV -2-neutralizing antibodies, SC 31 |
| الوصف: |
( A ) Disease progression in K18 mice as shown by weight loss (left) and survival (right). ( B ) Kinetics of viral infection in K18 mice with lung viral load based on genome copies (left) and infectious disease (right). The dotted line indicates the limit of detection (LOD). ( C ). Kinetics of the cytokine response in the lung as measured by mRNA expression of pro-inflammatory cytokines IFNβ, TNF, IL1b, IL6 and chemokines CCL2, CXCL10 represented as fold-change over uninfected mice. Each point represents one individual mouse with the mean indicated by the horizontal lines or bars. Statistical significance between viral load on adjacent days was determined using Student’s t-test. (TIF) |
| نوع الوثيقة: |
still image |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/figure/Establishment_of_K-18_human_ACE2_transgenic_mouse_SARS-CoV-2_infection_model_/14830470 |
| DOI: |
10.1371/journal.pone.0253487.s003 |
| الاتاحة: |
https://doi.org/10.1371/journal.pone.0253487.s003 |
| Rights: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.BBE460F3 |
| قاعدة البيانات: |
BASE |