Academic Journal
Alteration of microbiota antibody‐mediated immune selection contributes to dysbiosis in inflammatory bowel diseases
| العنوان: | Alteration of microbiota antibody‐mediated immune selection contributes to dysbiosis in inflammatory bowel diseases |
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| المؤلفون: | Michaud, Eva, Waeckel, Louis, Gayet, Rémi, Goguyer‐deschaumes, Roman, Chanut, Blandine, Jospin, Fabienne, Bathany, Katell, Monnoye, Magali, Genet, Coraline, Prier, Amelie, Tokarski, Caroline, Gérard, Philippe, Roblin, Xavier, Rochereau, Nicolas, Paul, Stéphane |
| المساهمون: | Physiopathologie et biothérapies des infections muqueuses CIRI (CIRI-GIMAP), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon), Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Chimie et Biologie des Membranes et des Nanoobjets (CBMN), Université de Bordeaux (UB)-École Nationale d'Ingénieurs des Travaux Agricoles - Bordeaux (ENITAB)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS), MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) (RIGHT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang Bourgogne-Franche-Comté (EFS BFC)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté COMUE (UBFC)-Université Bourgogne Franche-Comté COMUE (UBFC), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Université Jean Monnet - Saint-Étienne (UJM), Centre Hospitalier Universitaire de Saint-Etienne CHU Saint-Etienne (CHU ST-E), Centre d'Investigation Clinique - Epidémiologie Clinique CHU Saint-Etienne (CIC-EC 1408), Centre Hospitalier Universitaire de Saint-Etienne CHU Saint-Etienne (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| المصدر: | ISSN: 1757-4676. |
| بيانات النشر: | CCSD Wiley Open Access |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | SIgA microbiota glycosylation IBD immunity Subject Categories Digestive System Immunology Microbiology, Virology &, Host Pathogen Interaction, SIgA, microbiota, glycosylation, IBD, immunity Subject Categories Digestive System, Immunology, Microbiology, [SDV.IMM.VAC]Life Sciences [q-bio]/Immunology/Vaccinology, [SDV.IMM]Life Sciences [q-bio]/Immunology, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology |
| الوصف: | International audience ; Human secretory immunoglobulins (SIg) A1 and SIgA2 guide mucosal responses toward tolerance or inflammation, notably through reverse-transcytosis, the apical-to-basal transport of IgA2 immune complexes via M cells of gut Peyer's patches. As such, the maintenance of a diverse gut microbiota requires broad affinity IgA and glycan-glycan interaction. Here, we asked whether IgA1 and IgA2-microbiota interactions might be involved in dysbiosis induction during inflammatory bowel diseases. Using stool HPLCpurified IgA, we show that reverse-transcytosis is abrogated in ulcerative colitis (UC) while it is extended to IgA1 in Crohn's disease (CD). 16S RNA sequencing of IgA-bound microbiota in CD and UC showed distinct IgA1-and IgA2-associated microbiota; the IgA1 + fraction of CD microbiota was notably enriched in beneficial commensals. These features were associated with increased IgA anti-glycan reactivity in CD and an opposite loss of reactivity in UC. Our results highlight previously unknown pathogenic properties of IgA in IBD that could support dysbiosis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.15252/emmm.202115386 |
| الاتاحة: | https://hal.science/hal-04871841 https://hal.science/hal-04871841v1/document https://hal.science/hal-04871841v1/file/EMMM-14-e15386.pdf https://doi.org/10.15252/emmm.202115386 |
| Rights: | http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.BBD70B7C |
| قاعدة البيانات: | BASE |
| DOI: | 10.15252/emmm.202115386 |
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