Academic Journal
Prenatal paraben exposure and anogenital distance and reproductive hormones during mini-puberty:A study from the Odense Child Cohort
| العنوان: | Prenatal paraben exposure and anogenital distance and reproductive hormones during mini-puberty:A study from the Odense Child Cohort |
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| المؤلفون: | Jensen, Tina Kold, Andersson, Anna Maria, Main, Katharina M., Johannsen, Trine Holm, Andersen, Marianne S., Kyhl, Henriette Boye, Juul, Anders, Frederiksen, Hanne |
| المصدر: | Jensen , T K , Andersson , A M , Main , K M , Johannsen , T H , Andersen , M S , Kyhl , H B , Juul , A & Frederiksen , H 2021 , ' Prenatal paraben exposure and anogenital distance and reproductive hormones during mini-puberty : A study from the Odense Child Cohort ' , Science of the Total Environment , vol. 769 , 145119 . https://doi.org/10.1016/j.scitotenv.2021.145119 |
| سنة النشر: | 2021 |
| المجموعة: | University of Southern Denmark: Research Output / Syddansk Universitet |
| مصطلحات موضوعية: | Anogenital distance, Parabens, Reproductive hormones |
| الوصف: | Background: Parabens are added to personal care products as antimicrobial preservatives. They have been suggested to have endocrine disrupting abilities. Prenatal exposure to parabens has been associated with reproductive endpoints including reduced male anogenital distance (AGD, distance from anus to genitals), which is sensitive to prenatal anti-androgenic exposure. Objectives: To study the associations between maternal paraben concentrations in second trimester urine and AGD and reproductive hormone concentrations at 3 months of age in offspring. Methods: Pregnant women from Odense, Denmark were included in early pregnancy from 2010 to 12, and their children are being followed up. Fasting spot urine samples from 536 pregnant women were analyzed for methylparaben (MeP), ethyl-paraben (EtP), iso-propylparaben (i-PrP), n-propylparaben (n-PrP), n-butylparaben (n-BuP) and benzylparaben (BzP) by liquid chromatography tandem mass spectrometry and thereafter osmolarity adjusted. Three months after expected date of birth, AGD was measured in 452 children, and serum concentrations of follicle stimulating hormone (FSH), luteinizing (LH), testosterone, dehydroepiandrosterone-sulphate (DHEAS), androstenedione and 17-hydroxyprogesterone (17-OHP) were measured in 198 children. Maternal paraben exposure was categorized into tertiles or below and above level of detection, and sex-stratified multiple linear regression analyses were performed with AGD or reproductive hormones as outcomes. Results: Most pregnant women had low concentrations of parabens in urine, but 10% exceeded the threshold for adverse estrogenic effects. Higher maternal paraben exposure was associated with shorter AGD in male offspring and longer AGD in girls, although only significant for MeP in boys. In addition, FSH, LH, DHEAS, 17-OHP concentrations were lower in girls with high prenatal paraben exposure, whereas no consistent pattern was found in boys. Discussion: The endocrine disrupting abilities of parabens may affect humans at vulnerable time periods ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1016/j.scitotenv.2021.145119 |
| الاتاحة: | https://portal.findresearcher.sdu.dk/da/publications/00885d75-9835-4ba7-a95e-2b5fadc7aba5 https://doi.org/10.1016/j.scitotenv.2021.145119 https://findresearcher.sdu.dk/ws/files/179069305/Jensen_2021_Prenatal_paraben_exposure_and_anoge.pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.BB911932 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.scitotenv.2021.145119 |
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