Academic Journal
Prevalence and screening costs of hepatitis C virus among Ugandan blood donors
| العنوان: | Prevalence and screening costs of hepatitis C virus among Ugandan blood donors |
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| المؤلفون: | Hladik, W., Kataaha, P., Mermin, J., Purdy, M., Otekat, G., Lackritz, E., Alter, M. J., Downing, R. |
| المصدر: | Tropical Medicine & International Health ; volume 11, issue 6, page 951-954 ; ISSN 1360-2276 1365-3156 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2006 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Summary Background Screening donated blood for hepatitis C virus (HCV) is important for HCV prevention and is routinely practiced in North America and Europe. However, in many African countries little is known about HCV prevalence or cost‐effectiveness of HCV antibody (anti‐HCV) screening. Methods We investigated 2592 plasma specimens collected consecutively from blood donors in central Uganda in 1999. Routine screening by the blood bank included human immunodeficiency virus (HIV), hepatitis B surface antigen (HBsAg), and syphilis. To assess HCV prevalence and cost‐effectiveness of testing, specimens were additionally tested for anti‐HCV IgG by enzyme immunosorbent assay (EIA). Specimens repeatedly reactive (RR) on EIA were tested with a recombinant immunoblot assay (RIBA). Results Overall, 107 (4.1%) specimens were HCV EIA RR. Fifteen EIA RR specimens (0.6%, 95% confidence interval = 0.3–0.9%) were RIBA positive and 47 (1.8%) were RIBA indeterminate. Most (80%) RIBA‐positive specimens were non‐reactive for HIV, HBsAg, and syphilis. RIBA positivity was not associated with donor age, sex, number of donations, HIV, or HBsAg positivity. Costs of screening donors for anti‐HCV by using EIA were estimated at US$782 per potential transfusion‐associated HCV infection (exposure to RIBA‐positive blood) averted. Conclusions Current screening tests for other infections are ineffective in removing HCV‐positive donations. Testing costs are considerable; cost‐effectiveness of identifying HCV‐infected donors will be critical in decision making about HCV screening in Uganda. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/j.1365-3156.2006.01643.x |
| الاتاحة: | http://dx.doi.org/10.1111/j.1365-3156.2006.01643.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-3156.2006.01643.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-3156.2006.01643.x |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.BB73BA3C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/j.1365-3156.2006.01643.x |
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