Academic Journal
Outcomes of both abbreviated hyper‐ CVAD induction followed by autologous hematopoietic cell transplantation and conventional chemotherapy for mantle cell lymphoma: a 10‐year single‐centre experience with literature review
| العنوان: | Outcomes of both abbreviated hyper‐ CVAD induction followed by autologous hematopoietic cell transplantation and conventional chemotherapy for mantle cell lymphoma: a 10‐year single‐centre experience with literature review |
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| المؤلفون: | Alwasaidi, Turki Abdulaziz, Hamadah, Abdulaziz, Altouri, Sultan, Tay, Jason, McDiarmid, Sheryl, Faught, Carolyn, Allan, David, Huebsch, Lothar, Bredeson, Christopher, Bence‐Bruckler, Isabelle |
| المساهمون: | Saudi Arabian Cultural Bureau in Canada |
| المصدر: | Cancer Medicine ; volume 4, issue 12, page 1817-1827 ; ISSN 2045-7634 2045-7634 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2015 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | We retrospectively evaluated consecutive patients diagnosed with Mantle cell lymphoma ( MCL ) between 01 January 2000 and 31 December 2009. Eighty eight patients with MCL were included in the analysis of whom 46 (52%) received abbreviated Hyper‐ CVAD (a total of two cycles; with addition of Rituximab since 2005) with an intention of proceeding to autologous hematopoietic cell transplantation (auto‐ HCT ), with a median age of 58 years. Response rate to induction at auto‐ HCT time was 89% and complete response was 61%. Forty four patients received an auto‐ HCT with a 5‐year progression‐free survival ( PFS ) and overall survival ( OS ) were 31.2% and 62.5%, respectively. There were 42 nontransplant eligible patients with a median age of 72 years, and 5‐year PFS and OS were 0.0% and 39.9%, respectively. The median survival and PFS in the auto‐ HCT eligible group were 68 and 33 months, compared to 32 and 12 months in nontransplant eligible group, without a plateauing of the survival curves in either group. Treatment‐related mortality in the auto‐ HCT eligible group was 10.9% ( n = 5); two patients died during R‐Hyper‐ CVAD and 3 (6.8%) experienced transplant‐related mortality. An abbreviated R‐Hyper‐ CVAD ‐based induction strategy followed by consolidative auto‐ HCT is feasible and provides moderate potential of long‐term survival. Further research to define risk‐adapted strategies; to optimize disease control, is required. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/cam4.543 |
| الاتاحة: | http://dx.doi.org/10.1002/cam4.543 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcam4.543 https://onlinelibrary.wiley.com/doi/pdf/10.1002/cam4.543 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/cam4.543 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.BB72A367 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/cam4.543 |
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