Academic Journal
Development and characterization of nanobubbles containing paclitaxel and survivin inhibitor YM155 against lung cancer
| العنوان: | Development and characterization of nanobubbles containing paclitaxel and survivin inhibitor YM155 against lung cancer |
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| المؤلفون: | Erel-Akbaba G., Başpınar Y., Kotmakçı M., Akbaba H. |
| بيانات النشر: | Elsevier B.V. |
| سنة النشر: | 2019 |
| المجموعة: | Ege University Institutional Repository |
| مصطلحات موضوعية: | Nanobubble, Lung cancer, Paclitaxel, Survivin, Ultrasound, YM155 |
| الوصف: | PubMed ID: 31129344 ; Lung cancer remains 23% of cancer-related death worldwide, ranking on first place for men and second place for women. Almost each cancer type has a great deal in common, overexpression of the apoptosis inhibitor survivin. Chemotherapy with anticancer drugs is leading to side effects. Drug targeting by the use of nanobubbles is a useful strategy to reduce side effects. Nanobubbles in cancer are one of the most investigated carriers in the last years. The size of nanobubbles (1–500 nm)is bigger than the pore size of healthy tissues, but smaller than the pores of cancer tissues. Thus, it is not possible for the drug to leave the blood stream and enter the tissue, but it can enter the cancer tissue through the pores, where it can accumulate. Therefore, the probability of undesired side effects decreases. For that reason, the development of nanobubbles containing paclitaxel and survivin inhibitor sepantronium bromide (YM155)were carried out. Characterization studies in terms of pArticle size, size distribution, zeta potential and morphology, and investigation of their effects on lung cancer cells were performed. To the best of our knowledge, there is no information in the literature about combining paclitaxel and YM155 loaded nanobubbles with ultrasound exposure. © 2019 ; This study has been financially supported by the Scientific and Technological Research Council of Turkey (TUBITAK) under grant code 116S213. -- ; 116S213 Türkiye Bilimsel ve Teknolojik Araştirma Kurumu |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0378-5173 |
| Relation: | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; International Journal of Pharmaceutics; https://hdl.handle.net/11454/15639; https://doi.org/10.1016/j.ijpharm.2019.05.039; 566; 149; 156 |
| DOI: | 10.1016/j.ijpharm.2019.05.039 |
| الاتاحة: | https://hdl.handle.net/11454/15639 https://doi.org/10.1016/j.ijpharm.2019.05.039 |
| Rights: | none |
| رقم الانضمام: | edsbas.BB6BFFCE |
| قاعدة البيانات: | BASE |
| تدمد: | 03785173 |
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| DOI: | 10.1016/j.ijpharm.2019.05.039 |