Academic Journal
Efficacy of plasma exchange in patients with ischemia-reperfusion syndrome of the lower extremities
| العنوان: | Efficacy of plasma exchange in patients with ischemia-reperfusion syndrome of the lower extremities |
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| المؤلفون: | M S Zhigalova, I N Pasechnik, D E Kutepov |
| المصدر: | Kazanskij Medicinskij Žurnal, Vol 100, Iss 1, Pp 130-134 (2019) |
| بيانات النشر: | ECO-vector |
| سنة النشر: | 2019 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | syndrome of ischemia-reperfusion, critical limb ischemia, plasma exchange, Medicine |
| الوصف: | Aim. Optimization of treatment of patients with critical lower limb ischemia in ischemia-reperfusion syndrome by a combination of infusion therapy and plasma exchange. Methods. The study included 58 patients (48 men, 10 women) aged 52 to 87 years (mean age 67.1±6.2 years) operated for critical lower limb ischemia. In the postoperative period all patients received standard conservative treatment. Depending on its effectiveness, the patients were divided into two groups: group 1 (n=30) with a positive response to the treatment and group 2 (n=28) where plasma exchange was required. The indications for plasma exchange were a decrease in the rate of diuresis <0.5 ml/kg/h after the surgery for 4-6 hours, exceeding 5 times the normal values of creatine phosphokinase and 3 times the level of myoglobin. Results. In 48% of patients (group 2), deterioration of the condition was registered, which manifested by deterioration of the state, increase in shortness of breath, decrease in the rate of diuresis. In the laboratory analysis of patients of group 2, attention was drawn to an increase in the level of myoglobin to 287.8±30.1 ng/ml, creatine phosphokinase activity to 1769.3±191.8 u/l, and that of lactate to 2.2±0.3 mmol/l. These parameters exceeded not only the normal values, but also the indicators of group 1. These changes indicated the manifestation of ischemia-reperfusion syndrome and the threat of acute kidney injury. Plasma exchange was accompanied by clinical improvement (decrease in shortness of breath, increase in the rate of diuresis) and pronounced positive dynamics of laboratory parameters. The inclusion of plasma exchange into the complex therapy of ischemia-reperfusion syndrome was accompanied by an increase in the rate of diuresis by 1.7 times (p <0.05), a decrease in the level of myoglobin by 3.1 times (p <0.05) and the activity of creatine phosphokinase by 2.8 times (p <0.05). Conclusion. The use of plasma exchange during the first hours of clinical and laboratory manifestations of ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | Russian |
| تدمد: | 0368-4814 2587-9359 |
| Relation: | https://kazanmedjournal.ru/kazanmedj/article/viewFile/11014/8677; https://doaj.org/toc/0368-4814; https://doaj.org/toc/2587-9359; https://doaj.org/article/94dc836f512f40578c3da01e0e8c93f4 |
| DOI: | 10.17816/KMJ2019-130 |
| الاتاحة: | https://doi.org/10.17816/KMJ2019-130 https://doaj.org/article/94dc836f512f40578c3da01e0e8c93f4 |
| رقم الانضمام: | edsbas.BB52C9A |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 03684814 25879359 |
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| DOI: | 10.17816/KMJ2019-130 |