Academic Journal
Beliefs About Medicines Predict Side-Effects of Placebo Modafinil
| العنوان: | Beliefs About Medicines Predict Side-Effects of Placebo Modafinil |
|---|---|
| المؤلفون: | Heller, Monika K, Chapman, Sarah CE, Horne, Rob |
| المصدر: | Annals of Behavioral Medicine , 56 (10) pp. 989-1001. (2022) |
| بيانات النشر: | Springer Verlag |
| سنة النشر: | 2022 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | Beliefs about Medicines Questionnaire (BMQ), Medication beliefs, Necessity Concerns Framework (NCF), Nocebo, Nocebo mechanisms, Open-label placebo |
| الوصف: | BACKGROUND: Patients receiving placebo in clinical trials often report side-effects (nocebo effects), but contributing factors are still poorly understood. PURPOSE: Using a sham trial of the cognition-enhancing "smart pill" Modafinil we tested whether medication beliefs and other psychological factors predicted detection and attribution of symptoms as side-effects to placebo. METHODS: Healthy students (n = 201) completed measures assessing beliefs about medication, perceived sensitivity to medicines, negative affectivity, somatization, and body awareness; 66 were then randomized to receive Deceptive Placebo (told Modafinil-given placebo, 67 to Open Placebo (told placebo-given placebo, and 68 to No Placebo. Memory and attention tasks assessed cognitive enhancement. Nocebo effects were assessed by symptom checklist. RESULTS: More symptoms were reported in the Deceptive Placebo condition (M = 2.65; SD = 2.27) than Open Placebo (M = 1.92; SD = 2.24; Mann-Whitney U = 1,654, z = 2.30, p = .022) or No Placebo (M = 1.68; SD = 1.75, Mann-Whitney U = 1,640, z = 2.74, p = .006). Participants were more likely to attribute symptoms to Modafinil side-effects if they believed pharmaceuticals to be generally harmful (incidence rate ratio [IRR] = 1.70, p = .019), had higher perceived sensitivity to medicines (IRR = 1.68, p = .011), stronger concerns about Modafinil (IRR = 2.10, p < .001), and higher negative affectivity (IRR = 2.37, p < .001). CONCLUSIONS: Beliefs about medication are potentially modifiable predictors of the nocebo effect. These findings provide insight into side-effect reports to placebo and, potentially, active treatment. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| Relation: | https://discovery.ucl.ac.uk/id/eprint/10165356/1/Modafinil_revised_ms_updated_.pdf; https://discovery.ucl.ac.uk/id/eprint/10165356/ |
| الاتاحة: | https://discovery.ucl.ac.uk/id/eprint/10165356/1/Modafinil_revised_ms_updated_.pdf https://discovery.ucl.ac.uk/id/eprint/10165356/ |
| Rights: | open |
| رقم الانضمام: | edsbas.BB4D8EB5 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |