Academic Journal
Prevotella timonensis Bacteria Associated With Vaginal Dysbiosis Enhance Human Immunodeficiency Virus Type 1 Susceptibility Of Vaginal CD4+ T Cells
| العنوان: | Prevotella timonensis Bacteria Associated With Vaginal Dysbiosis Enhance Human Immunodeficiency Virus Type 1 Susceptibility Of Vaginal CD4+ T Cells |
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| المؤلفون: | van Teijlingen, Nienke H, van Smoorenburg, Marleen Y, Sarrami-Forooshani, Ramin, Zijlstra-Willems, Esther M, van Hamme, John L, Borgdorff, Hanneke, van de Wijgert, Janneke H H M, van Leeuwen, Elisabeth, van der Post, Joris A M, Strijbis, Karin, Ribeiro, Carla M S, Geijtenbeek, Teunis B H |
| المساهمون: | Dutch Research Council, European Research Council |
| المصدر: | The Journal of Infectious Diseases ; volume 230, issue 1, page e43-e47 ; ISSN 0022-1899 1537-6613 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2024 |
| الوصف: | Dysbiosis of the vaginal microbiome poses a serious risk for sexual human immunodeficiency virus type 1 (HIV-1) transmission. Prevotella spp are abundant during vaginal dysbiosis and associated with enhanced HIV-1 susceptibility; however, underlying mechanisms remain unclear. Here, we investigated the direct effect of vaginal bacteria on HIV-1 susceptibility of vaginal CD4+ T cells. Notably, pre-exposure to Prevotella timonensis enhanced HIV-1 uptake by vaginal T cells, leading to increased viral fusion and enhanced virus production. Pre-exposure to antiretroviral inhibitors abolished P timonensis–enhanced infection. Our study shows that the vaginal microbiome directly affects mucosal CD4+ T-cell susceptibility, emphasizing importance of vaginal dysbiosis diagnosis and treatment. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/infdis/jiae166 |
| DOI: | 10.1093/infdis/jiae166/57400329/jiae166.pdf |
| الاتاحة: | http://dx.doi.org/10.1093/infdis/jiae166 https://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiae166/57400329/jiae166.pdf https://academic.oup.com/jid/article-pdf/230/1/e43/58649352/jiae166.pdf |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.BAEFCB0B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/infdis/jiae166 |
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