Academic Journal
Transmission of trained immunity and heterologous resistance to infections across generations.
| العنوان: | Transmission of trained immunity and heterologous resistance to infections across generations. |
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| المؤلفون: | Cirovic, B., Renieris, G., Ciarlo, E., Le Roy, D., Lepikhov, K., Kattler, K., Gasparoni, G., Händler, K., Theis, H., Beyer, M., van der Meer, JWM, Joosten, LAB, Walter, J., Schultze, J.L. |
| المصدر: | Nature immunology, vol. 22, no. 11, pp. 1382-1390 |
| سنة النشر: | 2021 |
| المجموعة: | Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| مصطلحات موضوعية: | Animals, Candida albicans/immunology, Candida albicans/pathogenicity, Candidiasis/genetics, Candidiasis/immunology, Candidiasis/metabolism, Candidiasis/microbiology, Cells, Cultured, DNA Methylation, Disease Models, Animal, Epigenesis, Genetic, Escherichia coli/immunology, Escherichia coli/pathogenicity, Escherichia coli Infections/genetics, Escherichia coli Infections/immunology, Escherichia coli Infections/metabolism, Escherichia coli Infections/microbiology, Heredity, Host-Pathogen Interactions, Immunity, Innate/genetics, Listeria monocytogenes/immunology, Listeria monocytogenes/pathogenicity, Listeriosis/genetics, Listeriosis/immunology, Listeriosis/metabolism, Listeriosis/microbiology |
| الوصف: | Intergenerational inheritance of immune traits linked to epigenetic modifications has been demonstrated in plants and invertebrates. Here we provide evidence for transmission of trained immunity across generations to murine progeny that survived a sublethal systemic infection with Candida albicans or a zymosan challenge. The progeny of trained mice exhibited cellular, developmental, transcriptional and epigenetic changes associated with the bone marrow-resident myeloid effector and progenitor cell compartment. Moreover, the progeny of trained mice showed enhanced responsiveness to endotoxin challenge, alongside improved protection against systemic heterologous Escherichia coli and Listeria monocytogenes infections. Sperm DNA of parental male mice intravenously infected with the fungus C. albicans showed DNA methylation differences linked to immune gene loci. These results provide evidence for inheritance of trained immunity in mammals, enhancing protection against infections. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/34663978; info:eu-repo/semantics/altIdentifier/eissn/1529-2916; info:eu-repo/grantAgreement/SNF/Projects/310030_173123///; info:eu-repo/grantAgreement/OTHER//Fondation Carigest///; info:eu-repo/grantAgreement/OTHER//Fondation de Recherche en Biochimie///; https://serval.unil.ch/notice/serval:BIB_66EB4A759670; https://serval.unil.ch/resource/serval:BIB_66EB4A759670.P001/REF.pdf |
| DOI: | 10.1038/s41590-021-01052-7 |
| الاتاحة: | https://serval.unil.ch/notice/serval:BIB_66EB4A759670 https://doi.org/10.1038/s41590-021-01052-7 https://serval.unil.ch/resource/serval:BIB_66EB4A759670.P001/REF.pdf |
| Rights: | info:eu-repo/semantics/restrictedAccess ; Restricted: indefinite embargo ; Copying allowed only for non-profit organizations ; https://serval.unil.ch/disclaimer |
| رقم الانضمام: | edsbas.BAE3B8D4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41590-021-01052-7 |
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