Academic Journal
Impact of concomitant gastroesophageal reflux disease symptomology on prognosis and pulmonary function of chronic hypersensitivity pneumonitis
| العنوان: | Impact of concomitant gastroesophageal reflux disease symptomology on prognosis and pulmonary function of chronic hypersensitivity pneumonitis |
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| المؤلفون: | Wiaam Y Elkhatib, Scott A Helgeson, Hassan Z Baig, Augustine S Lee |
| المصدر: | Lung India, Vol 40, Iss 5, Pp 406-411 (2023) |
| بيانات النشر: | Wolters Kluwer Medknow Publications |
| سنة النشر: | 2023 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | chp, chronic hypersensitivity pneumonitis, gastroesophageal reflux disease, gerd, Diseases of the respiratory system, RC705-779 |
| الوصف: | Background and Objectives: Comorbid risk factors in chronic hypersensitivity pneumonitis (CHP) are poorly characterised. Gastroesophageal reflux disease (GERD) is linked to interstitial lung diseases like idiopathic pulmonary fibrosis (IPF), but its association and treatment in CHP is less understood. This study aims to understand the role and prevalence of GERD in CHP, plus the effect of GERD treatment on lung function and mortality. Methods: A tertiary referral centre panel was retrospectively reviewed for 214 patients diagnosed with CHP based on clinical history, bronchoalveolar lavage fluid analysis, imaging and histopathology. GERD diagnostic criteria included symptomology, acid suppressive therapy use and diagnostic testing. CHP patients with GERD (n = 89) and without GERD (n = 125) were compared via descriptive statistical analysis. Pulmonary function, GERD diagnosis plus treatment and other comorbidities were evaluated against CHP outcomes. Results: Respective differences between diagnosis and study termination dates in the GERD population versus without GERD for functional vital capacity (FVC) were − 1 L vs − 2.5 L, diffusing capacity of the lungs for carbon monoxide (DLCO) were − 2 mL/min/mmHg versus − 1 mL/min/mmHg, per cent alive at the time of study 88% versus 81%, median date of survival 574.5 versus 850 and supplemental oxygen requirement 41% versus 37%. GERD prevalence was higher in CHP patients relative to the general population. No statistical significance was found between survival curves, oxygen requirement, smoking history, FVC, or DLCO. Conclusions: GERD could be a harmful comorbidity in CHP though may not necessarily affect survival or functional outcomes. This aligns with previous IPF studies, though remains controversial. Further research is needed regarding this association and treatment benefit. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0970-2113 0974-598X |
| Relation: | http://www.lungindia.com/article.asp?issn=0970-2113;year=2023;volume=40;issue=5;spage=406;epage=411;aulast=Elkhatib; https://doaj.org/toc/0970-2113; https://doaj.org/toc/0974-598X; https://doaj.org/article/ada709d760d2405b8b1fbfc729f8c216 |
| DOI: | 10.4103/lungindia.lungindia_107_23 |
| الاتاحة: | https://doi.org/10.4103/lungindia.lungindia_107_23 https://doaj.org/article/ada709d760d2405b8b1fbfc729f8c216 |
| رقم الانضمام: | edsbas.BAA1C2DF |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 09702113 0974598X |
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| DOI: | 10.4103/lungindia.lungindia_107_23 |