Academic Journal
Long-term disease control in dedifferentiated liposarcoma: a case report on trabectedin priming followed by PD-1 inhibition
| العنوان: | Long-term disease control in dedifferentiated liposarcoma: a case report on trabectedin priming followed by PD-1 inhibition |
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| المؤلفون: | Johannes M. Waldschmidt, Lukas Haug, Christine Riedhammer, Christoph K. W. Deinzer, Marcus Zimmermann, Anke Heidemeier, Peter Raab, Maximilian Rudert, Anne Hendricks, Johan F. Lock, Viktoria Buck, Andreas Rosenwald, Hermann Einsele, Peter Reichardt, Volker Kunzmann, Armin Wiegering, Daniel Pink, K. Martin Kortüm |
| المصدر: | Frontiers in Oncology, Vol 14 (2025) |
| بيانات النشر: | Frontiers Media S.A. |
| سنة النشر: | 2025 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | sarcoma, dedifferentiated liposarcoma, checkpoint inhibition, PD-1, immune microenvironment, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | BackgroundDedifferentiated liposarcoma (DDLPS) is a rare mesenchymal cancer originating from the adipose tissue, with poor survival rates for most patients, highlighting the critical need for novel treatment options.Case descriptionThis report examines the efficacy and safety of sequential pre-treatment with the marine-derived alkaloid trabectedin followed by checkpoint inhibition using the anti-PD-1 antibody nivolumab in a 63-year-old male patient with unresectable retroperitoneal DDLPS. Treatment was initiated at the time of the seventh relapse as part of the NitraSarc phase 2 multicenter trial for inoperable soft tissue sarcoma conducted by the German Interdisciplinary Sarcoma Group (GISG-15, NCT03590210). The patient demonstrated an immediate tumor response, and in combination with minor surgery, achieved R0 resection status, which was subsequently maintained without the need for further therapy for the past 52 months. Correlative molecular analyses revealed a sustained DNA damage repair machinery and downregulation of PD-1 protein expression in post-treatment tumor samples.ConclusionThis report provides exemplary insight on the feasibility and efficacy of sequential pre-treatment with trabectedin as a priming strategy for PD-1 inhibition in advanced DDLPS. Full trial results from NitraSarc are pending for publication. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1518775/full; https://doaj.org/toc/2234-943X; https://doaj.org/article/dc75985da14a49368e453b52e7b5410b |
| DOI: | 10.3389/fonc.2024.1518775 |
| الاتاحة: | https://doi.org/10.3389/fonc.2024.1518775 https://doaj.org/article/dc75985da14a49368e453b52e7b5410b |
| رقم الانضمام: | edsbas.BA883B08 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fonc.2024.1518775 |
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