Academic Journal
Cardiac “hypertrophy” phenotyping: differentiating aetiologies with increased left ventricular wall thickness on echocardiography
| العنوان: | Cardiac “hypertrophy” phenotyping: differentiating aetiologies with increased left ventricular wall thickness on echocardiography |
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| المؤلفون: | Ferkh, Aaisha, Tjahjadi, Catherina, Stefani, Luke, Geenty, Paul, Byth, Karen, De Silva, Kasun, Boyd, Anita C., Richards, David, Mollee, Peter, Korczyk, Dariusz, Taylor, Mark S., Kwok, Fiona, Kizana, Eddy, Ng, Arnold C. T., Thomas, Liza |
| المصدر: | Frontiers in Cardiovascular Medicine ; volume 10 ; ISSN 2297-055X |
| بيانات النشر: | Frontiers Media SA |
| سنة النشر: | 2023 |
| المجموعة: | Frontiers (Publisher - via CrossRef) |
| الوصف: | Aims Differentiating phenotypes of cardiac “hypertrophy” characterised by increased wall thickness on echocardiography is essential for management and prognostication. Transthoracic echocardiography is the most commonly used screening test for this purpose. We sought to identify echocardiographic markers that distinguish infiltrative and storage disorders that present with increased left ventricular (LV) wall thickness, namely, cardiac amyloidosis (CA) and Anderson–Fabry disease (AFD), from hypertensive heart disease (HHT). Methods Patients were retrospectively recruited from Westmead Hospital, Sydney, and Princess Alexandra Hospital, Brisbane. LV structural, systolic, and diastolic function parameters, as well as global (LVGLS) and segmental longitudinal strains, were assessed. Previously reported echocardiographic parameters including relative apical sparing ratio (RAS), LV ejection fraction-to-strain ratio (EFSR), mass-to-strain ratio (MSR) and amyloidosis index (AMYLI) score (relative wall thickness × E / e ′) were evaluated. Results A total of 209 patients {120 CA [58 transthyretin amyloidosis (ATTR) and 62 light-chain (AL) amyloidosis], 31 AFD and 58 HHT patients; mean age 64.1 ± 13.7 years, 75% male} comprised the study cohort. Echocardiographic measurements differed across the three groups, The LV mass index was higher in both CA {median 126.6 [interquartile range (IQR) 106.4–157.9 g/m 2 ]} and AFD [median 134 (IQR 108.8–152.2 g/m 2 )] vs. HHT [median 92.7 (IQR 79.6–102.3 g/m 2 ), p < 0.05]. LVGLS was lowest in CA [median 12.29 (IQR 10.33–15.56%)] followed by AFD [median 16.92 (IQR 14.14–18.78%)] then HHT [median 18.56 (IQR 17.51–19.97%), p < 0.05]. Diastolic function measurements including average e ′ and E / e ′ were most impaired in CA and least impaired in AFD. Indexed left atrial volume was highest in CA. EFSR and MSR differentiated secondary (CA + AFD) from HHT [receiver operating curve–area under the curve (ROC-AUC) of 0.80 and 0.91, respectively]. RAS and AMYLI score differentiated ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.3389/fcvm.2023.1183485 |
| DOI: | 10.3389/fcvm.2023.1183485/full |
| الاتاحة: | http://dx.doi.org/10.3389/fcvm.2023.1183485 https://www.frontiersin.org/articles/10.3389/fcvm.2023.1183485/full |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.BA7F3D5F |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fcvm.2023.1183485 |
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