Academic Journal
P352 Global myocardial wall strain decreases in patients with atrial fibrillation: a pilot cohort study
| العنوان: | P352 Global myocardial wall strain decreases in patients with atrial fibrillation: a pilot cohort study |
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| المؤلفون: | Pop, S, Budurea, C, Iliescu, A M, Iancu, S D, Coman, V, Manole, S, Coman, M, Ciortea, C, Balint, Z |
| المصدر: | European Heart Journal - Cardiovascular Imaging ; volume 21, issue Supplement_1 ; ISSN 2047-2404 2047-2412 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Cardiology and Cardiovascular Medicine, Radiology, Nuclear Medicine and imaging, General Medicine |
| الوصف: | Funding Acknowledgements Competitiveness Operational Programme 2014-2020 POC-A1-A1.1.4-E-2015, financed under the European Regional Development Fund, project number P_37_245 Background Atrial fibrillation (AF) is the most common human arrhythmia, associated with substantial morbidity and mortality. Histopathological studies of persistent AF have reported extracellular matrix remodelling with fibrotic infiltration in the myocardium, causing atrial dilation and electrical remodelling. Purpose In this pilot cohort study, we aimed to identify markers of persistent AF by comparing clinical data (ECG, echocardiography, cardiac MRI) from AF patients and age- and sex-matched healthy controls. Methods The study imATFIBis an observational, single-centre, cohort study (NCT03584126). The study was approved by the hospital ethics committee.Patients with AF visiting the outpatient clinic and healthy adult volunteers were examined clinically, by electrocardiography, echocardiography and cardiac MRI. For this primary analysis, we compared data from 16 patients (53 [50–59]YOA) and 16 age- and sex-matched controls (53.5 [50–59]YOA). We also compared AF patients with (N = 11; 67 [53–69]YOA) and without (N = 16; 56 [50–67]YOA) fibrosis (MRI). The unpaired Mann-Whitney t-test was used to test for significant differences. P values <0.05 were considered significant. Values are presented as medians and interquartile ranges, unless otherwise stated. Results Patients with AF presented a significant decrease in global myocardial wall strain as compared to healthy controls (-15%vs-19.5%, p = 0.008, N = 16), whereas there was no difference in their global ventricular systolic function (ejection fraction). Left atrial (LA) echocardiographic volume (110.90 [79.13–143.3] vs59.59 [43.32–69.50] cm3) and LA volume normalized to body surface area (BSA) (54.66 [41.00–70.83] vs32.71 [22.74–35.46] cm3/m2) were significantly higher in patients (all p < 0.001). Similarly, on cardiac MRI, a significantly increased LA volume of ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/ehjci/jez319.203 |
| الاتاحة: | http://dx.doi.org/10.1093/ehjci/jez319.203 http://academic.oup.com/ehjcimaging/article-pdf/21/Supplement_1/jez319.203/31864822/jez319.203.pdf |
| Rights: | https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model |
| رقم الانضمام: | edsbas.BA68F945 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ehjci/jez319.203 |
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